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• W2793731361 endingPage "481" @default.
• W2793731361 startingPage "463" @default.
• W2793731361 abstract "miRNA regulome is whole set of regulatory elements that regulate miRNA expression or are under control of miRNAs. Its understanding is vital for comprehension of miRNA functions. Classification of miRNA-related genetic variability is challenging because miRNA interact with different genomic elements and are studied at different omics levels. In the present study, miRNA-associated genetic variability is presented at three levels: miRNA genes and their upstream regulation, miRNA silencing machinery and miRNA targets. Several types of miRNA-associated genetic variations are known, including short and structural polymorphisms and epimutations. Differential expression can also affect miRNA regulome function. Classification of miRNA-associated genetic variability presents a baseline for complementing sequence variant nomenclature, planning of experiments, protocols for multi-omics data integration and development of biomarkers." @default.
• W2793731361 created "2018-03-29" @default.
• W2793731361 creator A5061940103 @default.
• W2793731361 creator A5077110623 @default.
• W2793731361 date "2018-04-01" @default.
• W2793731361 modified "2023-10-14" @default.
• W2793731361 title "Classification of miRNA-related sequence variations" @default.
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