FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2793740510> ?p ?o ?g. }

• W2793740510 abstract "ABSTRACT Background: Monocytes and macrophages are central to atherosclerosis, but how they mark progression of human coronary artery disease (CAD) is unclear. We tested whether patients’ monocyte subtypes paired with their derived macrophage profiles correlate with extent of CAD. Methods : Peripheral blood was collected from 30 patients undergoing cardiac catheterization, and patients were categorized as having no significant CAD, single vessel disease, or multivessel disease according to the number of affected coronary arteries. Mononuclear cells were measured for monocyte markers CD14 and CD16 by flow cytometry, and separate monocytes were cultured into macrophages over 7 days and measured for polarization markers CD86 and CD206. Results: At baseline, patients with greater CAD burden were older with higher rates of statin use, whereas all other characteristics were similar across the spectrum of coronary disease. Non-classical (CD14 lo CD16 hi ) and all CD16 + monocytes were elevated in patients with single vessel and multivessel disease compared to those without significant CAD (8.6% and 10.5% vs. 2.8%, p < 0.05), whereas regulatory M2 macrophages (CD206 + ) were decreased in patients with single vessel and multivessel disease (0.34% and 0.34% vs. 1.4%, p < 0.05). An inverse relationship between paired CD16 + monocytes and M2 macrophages marked CAD severity. CAD was also found to be more tightly associated with CD16 + cells than age or traditional cardiovascular risk factors on multiple regression analysis of these patients. Conclusions: CAD extent is correlated directly with CD16 + monocytes and inversely with M2 (CD206 + ) macrophages, suggesting circulating monocytes may influence downstream polarization of lesional macrophages. These measures of monocyte and macrophage subtypes hold potential as biomarkers in CAD." @default.
• W2793740510 created "2018-03-29" @default.
• W2793740510 creator A5009064124 @default.
• W2793740510 creator A5012410961 @default.
• W2793740510 creator A5019296866 @default.
• W2793740510 creator A5029385740 @default.
• W2793740510 creator A5052430845 @default.
• W2793740510 creator A5074165064 @default.
• W2793740510 date "2018-05-16" @default.
• W2793740510 modified "2023-09-27" @default.
• W2793740510 title "Monocyte and Macrophage Subtypes as Paired Cell Biomarkers for Coronary Artery Disease" @default.
• W2793740510 cites W110542923 @default.
• W2793740510 cites W150221401 @default.
• W2793740510 cites W1608693925 @default.
• W2793740510 cites W1964369726 @default.
• W2793740510 cites W1965306577 @default.
• W2793740510 cites W1977435414 @default.
• W2793740510 cites W1983501664 @default.
• W2793740510 cites W2003632211 @default.
• W2793740510 cites W2007199204 @default.
• W2793740510 cites W2008153755 @default.
• W2793740510 cites W2008207915 @default.
• W2793740510 cites W2017921631 @default.
• W2793740510 cites W2019680103 @default.
• W2793740510 cites W2035817205 @default.
• W2793740510 cites W2045891124 @default.
• W2793740510 cites W2046099126 @default.
• W2793740510 cites W2047600616 @default.
• W2793740510 cites W2052365898 @default.
• W2793740510 cites W2055665660 @default.
• W2793740510 cites W2057835664 @default.
• W2793740510 cites W2060070139 @default.
• W2793740510 cites W2068174131 @default.
• W2793740510 cites W2094941678 @default.
• W2793740510 cites W2120139005 @default.
• W2793740510 cites W2123658841 @default.
• W2793740510 cites W2140991303 @default.
• W2793740510 cites W2151105551 @default.
• W2793740510 cites W2158550197 @default.
• W2793740510 cites W2159861185 @default.
• W2793740510 cites W2160381081 @default.
• W2793740510 cites W2162405407 @default.
• W2793740510 cites W2419520222 @default.
• W2793740510 cites W2558476889 @default.
• W2793740510 cites W2794863947 @default.
• W2793740510 cites W4213245349 @default.
• W2793740510 doi "https://doi.org/10.1101/323287" @default.
• W2793740510 hasPublicationYear "2018" @default.
• W2793740510 type Work @default.
• W2793740510 sameAs 2793740510 @default.
• W2793740510 citedByCount "0" @default.
• W2793740510 crossrefType "posted-content" @default.
• W2793740510 hasAuthorship W2793740510A5009064124 @default.
• W2793740510 hasAuthorship W2793740510A5012410961 @default.
• W2793740510 hasAuthorship W2793740510A5019296866 @default.
• W2793740510 hasAuthorship W2793740510A5029385740 @default.
• W2793740510 hasAuthorship W2793740510A5052430845 @default.
• W2793740510 hasAuthorship W2793740510A5074165064 @default.
• W2793740510 hasBestOaLocation W27937405101 @default.
• W2793740510 hasConcept C114684123 @default.
• W2793740510 hasConcept C126322002 @default.
• W2793740510 hasConcept C137061746 @default.
• W2793740510 hasConcept C164705383 @default.
• W2793740510 hasConcept C167672396 @default.
• W2793740510 hasConcept C202751555 @default.
• W2793740510 hasConcept C203014093 @default.
• W2793740510 hasConcept C204232928 @default.
• W2793740510 hasConcept C2775858924 @default.
• W2793740510 hasConcept C2776460901 @default.
• W2793740510 hasConcept C2776820930 @default.
• W2793740510 hasConcept C2778213512 @default.
• W2793740510 hasConcept C2778513237 @default.
• W2793740510 hasConcept C2778742706 @default.
• W2793740510 hasConcept C2779244956 @default.
• W2793740510 hasConcept C2781184567 @default.
• W2793740510 hasConcept C2781462264 @default.
• W2793740510 hasConcept C553184892 @default.
• W2793740510 hasConcept C55493867 @default.
• W2793740510 hasConcept C71924100 @default.
• W2793740510 hasConcept C86803240 @default.
• W2793740510 hasConcept C8891405 @default.
• W2793740510 hasConcept C90924648 @default.
• W2793740510 hasConceptScore W2793740510C114684123 @default.
• W2793740510 hasConceptScore W2793740510C126322002 @default.
• W2793740510 hasConceptScore W2793740510C137061746 @default.
• W2793740510 hasConceptScore W2793740510C164705383 @default.
• W2793740510 hasConceptScore W2793740510C167672396 @default.
• W2793740510 hasConceptScore W2793740510C202751555 @default.
• W2793740510 hasConceptScore W2793740510C203014093 @default.
• W2793740510 hasConceptScore W2793740510C204232928 @default.
• W2793740510 hasConceptScore W2793740510C2775858924 @default.
• W2793740510 hasConceptScore W2793740510C2776460901 @default.
• W2793740510 hasConceptScore W2793740510C2776820930 @default.
• W2793740510 hasConceptScore W2793740510C2778213512 @default.
• W2793740510 hasConceptScore W2793740510C2778513237 @default.
• W2793740510 hasConceptScore W2793740510C2778742706 @default.
• W2793740510 hasConceptScore W2793740510C2779244956 @default.
• W2793740510 hasConceptScore W2793740510C2781184567 @default.
• W2793740510 hasConceptScore W2793740510C2781462264 @default.
• W2793740510 hasConceptScore W2793740510C553184892 @default.

• next