FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2793746632> ?p ?o ?g. }

• W2793746632 abstract "Notch inhibition is known to generate supernumerary hair cells (HCs) at the expense of supporting cells (SCs) in the mammalian inner ear. However, inhibition of Notch activity becomes progressively less effective at inducing SC-to-HC conversion in the postnatal cochlea and balance organs as the animal ages. It has been suggested that the SC-to-HC conversion capacity is inversely correlated with E-cadherin accumulation in postnatal mammalian utricles. However, whether E-cadherin localization is linked to the SC-to-HC conversion capacity in the mammalian inner ear is poorly understood. In the present study, we treated cochleae from postnatal day 0 (P0) with the Notch signaling inhibitor DAPT and observed apparent SC-to-HC conversion along with E-cadherin/p120ctn disruption in the sensory region. In addition, the SC-to-HC conversion capacity and E-cadherin/p120ctn disorganization were robust in the apex but decreased toward the base. We further demonstrated that the ability to regenerate HCs and the disruption of E-cadherin/p120ctn concomitantly decreased with age and ceased at P7, even after extended DAPT treatments. This timing is consistent with E-cadherin/p120ctn accumulation in the postnatal cochleae. These results suggest that the decreasing capacity of SCs to transdifferentiate into HCs correlates with E-cadherin/p120ctn localization in the postnatal cochleae, which might account for the absence of SC-to-HC conversion in the mammalian cochlea." @default.
• W2793746632 created "2018-03-29" @default.
• W2793746632 creator A5012098573 @default.
• W2793746632 creator A5021641125 @default.
• W2793746632 creator A5029489182 @default.
• W2793746632 creator A5035500130 @default.
• W2793746632 creator A5059446611 @default.
• W2793746632 creator A5064869764 @default.
• W2793746632 creator A5071734108 @default.
• W2793746632 creator A5081684786 @default.
• W2793746632 creator A5084685237 @default.
• W2793746632 date "2018-02-21" @default.
• W2793746632 modified "2023-10-12" @default.
• W2793746632 title "Junctional E-cadherin/p120-catenin Is Correlated with the Absence of Supporting Cells to Hair Cells Conversion in Postnatal Mice Cochleae" @default.
• W2793746632 cites W1479883635 @default.
• W2793746632 cites W1681097815 @default.
• W2793746632 cites W1934202741 @default.
• W2793746632 cites W1965099938 @default.
• W2793746632 cites W1967385749 @default.
• W2793746632 cites W1972509102 @default.
• W2793746632 cites W1972645639 @default.
• W2793746632 cites W1972763237 @default.
• W2793746632 cites W1975149745 @default.
• W2793746632 cites W1983986827 @default.
• W2793746632 cites W1986802403 @default.
• W2793746632 cites W1987537120 @default.
• W2793746632 cites W1992857468 @default.
• W2793746632 cites W1995048201 @default.
• W2793746632 cites W1999611910 @default.
• W2793746632 cites W2001569947 @default.
• W2793746632 cites W2005196594 @default.
• W2793746632 cites W2018207596 @default.
• W2793746632 cites W2020102102 @default.
• W2793746632 cites W2023914268 @default.
• W2793746632 cites W2026120980 @default.
• W2793746632 cites W2028916500 @default.
• W2793746632 cites W2031876645 @default.
• W2793746632 cites W2034193769 @default.
• W2793746632 cites W2035495803 @default.
• W2793746632 cites W2037011968 @default.
• W2793746632 cites W2038440214 @default.
• W2793746632 cites W2042690085 @default.
• W2793746632 cites W2045146348 @default.
• W2793746632 cites W2049828845 @default.
• W2793746632 cites W2049903984 @default.
• W2793746632 cites W2050863097 @default.
• W2793746632 cites W2054220475 @default.
• W2793746632 cites W2058497055 @default.
• W2793746632 cites W2063464173 @default.
• W2793746632 cites W2064657201 @default.
• W2793746632 cites W2066054477 @default.
• W2793746632 cites W2068004733 @default.
• W2793746632 cites W2072051141 @default.
• W2793746632 cites W2081026475 @default.
• W2793746632 cites W2085179400 @default.
• W2793746632 cites W2085550383 @default.
• W2793746632 cites W2086620281 @default.
• W2793746632 cites W2087160148 @default.
• W2793746632 cites W2100706309 @default.
• W2793746632 cites W2115094414 @default.
• W2793746632 cites W2118263188 @default.
• W2793746632 cites W2122877719 @default.
• W2793746632 cites W2129384667 @default.
• W2793746632 cites W2137581290 @default.
• W2793746632 cites W2139676627 @default.
• W2793746632 cites W2143202985 @default.
• W2793746632 cites W2156396097 @default.
• W2793746632 cites W2265125080 @default.
• W2793746632 cites W2331733158 @default.
• W2793746632 cites W2397007275 @default.
• W2793746632 cites W2503874169 @default.
• W2793746632 cites W2507434455 @default.
• W2793746632 cites W2512186838 @default.
• W2793746632 cites W2514039065 @default.
• W2793746632 cites W2606791246 @default.
• W2793746632 cites W2730455802 @default.
• W2793746632 cites W2739548489 @default.
• W2793746632 cites W2777399939 @default.
• W2793746632 doi "https://doi.org/10.3389/fnmol.2018.00020" @default.
• W2793746632 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5826362" @default.
• W2793746632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29515364" @default.
• W2793746632 hasPublicationYear "2018" @default.
• W2793746632 type Work @default.
• W2793746632 sameAs 2793746632 @default.
• W2793746632 citedByCount "6" @default.
• W2793746632 countsByYear W27937466322019 @default.
• W2793746632 countsByYear W27937466322020 @default.
• W2793746632 countsByYear W27937466322022 @default.
• W2793746632 countsByYear W27937466322023 @default.
• W2793746632 crossrefType "journal-article" @default.
• W2793746632 hasAuthorship W2793746632A5012098573 @default.
• W2793746632 hasAuthorship W2793746632A5021641125 @default.
• W2793746632 hasAuthorship W2793746632A5029489182 @default.
• W2793746632 hasAuthorship W2793746632A5035500130 @default.
• W2793746632 hasAuthorship W2793746632A5059446611 @default.
• W2793746632 hasAuthorship W2793746632A5064869764 @default.
• W2793746632 hasAuthorship W2793746632A5071734108 @default.
• W2793746632 hasAuthorship W2793746632A5081684786 @default.
• W2793746632 hasAuthorship W2793746632A5084685237 @default.
• W2793746632 hasBestOaLocation W27937466321 @default.

• next