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• W2793750340 endingPage "2933" @default.
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• W2793750340 abstract "The components of ubiquitin (Ub)-proteasome system, such as Ub, Ub adaptors, or proteasome subunits, are commonly accumulated with the aggregated proteins in inclusions, but how protein aggregates sequester Ub-related proteins remains elusive. Using N-terminal huntingtin (Htt-N552) and ataxin (Atx)-3 as model proteins, we investigated the molecular mechanism underlying sequestration of Ub adaptors by polyQ-expanded proteins. We found that polyQ-expanded Htt-N552 and Atx-3 sequester endogenous Ub adaptors, human RAD23 homolog B (hHR23B) and ubiquilin (UBQLN)-2, into inclusions. This sequestration effect is dependent on the UBA domains of Ub adaptors and the conjugated Ub of the aggregated proteins. Moreover, polyQ-expanded Htt-N552 and Atx-3 reduce the protein level of xeroderma pigmentosum group C (XPC) by sequestration of hHR23B, suggesting that this process may cut down the available quantity of hHR23B and thus affect its normal function in stabilizing XPC. Our findings demonstrate that polyQ-expanded proteins sequester Ub adaptors or other Ub-related proteins into aggregates or inclusions through ubiquitination of the pathogenic proteins. This study may also provide a common mechanism for the formation of Ub-positive inclusions in cells.—Yang, H., Yue, H.-W., He, W.-T., Hong, J.-Y., Jiang, L.-L., Hu, H.-Y. PolyQ-expanded huntingtin and ataxin-3 sequester ubiquitin adaptors hHR23B and UBQLN2 into aggregates via conjugated ubiquitin. FASEB J. 32, 2923–2933 (2018). www.fasebj.org" @default.
• W2793750340 created "2018-03-29" @default.
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• W2793750340 date "2018-01-11" @default.
• W2793750340 modified "2023-10-07" @default.
• W2793750340 title "PolyQ‐expanded huntingtin and ataxin‐3 sequester ubiquitin adaptors hHR23B and UBQLN2 into aggregates <i>via</i> conjugated ubiquitin" @default.
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• W2793750340 cites W1975403755 @default.
• W2793750340 cites W1985474993 @default.
• W2793750340 cites W1985734261 @default.
• W2793750340 cites W1994645778 @default.
• W2793750340 cites W1995392239 @default.
• W2793750340 cites W2002559713 @default.
• W2793750340 cites W2003618511 @default.
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• W2793750340 doi "https://doi.org/10.1096/fj.201700801rr" @default.
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