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- W2793778598 abstract "To study the ability of post-radioembolization imaging response to predict overall survival in hepatocellular carcinoma (HCC). With IRB approval, we searched our prospectively acquired HCC database. 948 patients with HCC were treated with radioembolization (Y90) from 2003-2016. Patients with baseline metastases, vascular invasion, multifocal disease, Child-Pugh (CP) >B7, and transplanted/resected were excluded. This created our homogeneous study cohort of 134 patients with CP ≤B7 and solitary HCC. Response (using European Association for Study of the Liver [EASL] and Response Evaluation Criteria in Solid Tumors 1.1 [RECIST 1.1] criteria) was correlated with survival using Landmark and risk-of-death methodologies after reviewing 960 scans. Patients who showed complete or partial response to treatment at specific landmarks were considered as responders. In a subanalysis, survival times of responders were compared to those of patients with stable disease (SD) and progressive disease (PD). Uni/multivariate survival analyses were performed at each Landmark. At the 3-month landmark, responders survived longer than nonresponders by EASL (hazard ratio [HR], 0.46; confidence interval [CI], 0.26-0.82; P = 0.002) but not RECIST 1.1 criteria (HR, 0.70; CI, 0.37-1.32; P = 0.32). At the 6-month Landmark, responders survived longer than nonresponders by EASL (HR, 0.32; CI, 0.15-0.77; P< 0.001) and RECIST 1.1 criteria (HR, 0.50; CI, 0.29-0.87; P = 0.021). At the 12-month Landmark, responders survived longer than nonresponders by EASL (HR, 0.34; CI, 0.15-0.77; P< 0.001) and RECIST 1.1 criteria (HR, 0.52; CI 0.27-0.98; P = 0.049). At 6 months, risk of death was lower for responders by EASL (P< 0.001) and RECIST 1.1 (P = 0.0445). In subanalyses, responders lived longer than patients with SD or PD. EASL response was a significant predictor of survival at 3-, 6-, and 12-month Landmarks on uni/multivariate analyses. Response to Y90 in patients with solitary HCC can prognosticate improved survival. EASL necrosis criteria outperformed RECIST 1.1 size criteria in predicting survival. The therapeutic objective of radioembolization should be radiologic response and not solely to prevent progression." @default.
- W2793778598 created "2018-03-29" @default.
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- W2793778598 date "2018-04-01" @default.
- W2793778598 modified "2023-09-26" @default.
- W2793778598 title "Abstract No. 541 Radiologic response as a potential surrogate endpoint to overall survival in hepatocellular carcinoma patients undergoing radioembolization" @default.
- W2793778598 doi "https://doi.org/10.1016/j.jvir.2018.01.586" @default.
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