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- W2793865597 abstract "Abstract Piwi-interacting RNAs (piRNAs) control transposable elements widely across metazoans but have rapidly evolving biogenesis pathways. In Caenorhabditis elegans, almost all piRNA loci are found within two 3Mb clusters on Chromosome IV. Each piRNA locus possesses an upstream motif that recruits RNA polymerase II to produce a ∼28 nt precursor transcript. Here, we use comparative epigenomics across nematodes to gain insight into piRNA biogenesis. We show that the piRNA upstream motif is derived from core promoter elements controlling snRNA biogenesis. We describe two alternative modes of piRNA organisation in nematodes: in C. elegans and closely related nematodes, piRNAs are clustered within repressive H3K27me3 chromatin, whilst in other species, typified by Pristionchus pacificus, piRNAs are distributed genome-wide within introns of actively transcribed genes. In both groups, piRNA production depends on downstream sequence signals associated with RNA polymerase II pausing, which synergise with the chromatin environment to control piRNA precursor transcription." @default.
- W2793865597 created "2018-03-29" @default.
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- W2793865597 date "2018-03-13" @default.
- W2793865597 modified "2023-10-18" @default.
- W2793865597 title "Evolutionary analysis implicates RNA polymerase II pausing and chromatin structure in nematode piRNA biogenesis" @default.
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- W2793865597 doi "https://doi.org/10.1101/281360" @default.
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