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- W2793879025 abstract "Leucine-rich repeat kinase 2 (LRRK2) G2019S (glycine to serine) is the most common mutation associated with sporadic and familial Parkinson's disease (PD) with 80% penetrance by age 70. This mutation is found worldwide, with up to 40% of individuals in the North African Arab population carrying the mutation. Induced pluripotent stem cells derived from fibroblasts of patients carrying the LRRK2 G2019S mutation have been a critical source of cells for generating dopaminergic neurons and studying G2019S-related pathology. These studies have elucidated LRRK2-related mechanisms of mitochondrial dysregulation, increased reactive oxygen species, truncated and simplified neurites, and cell death. These phenotypes are thought to result from the G2019S mutation increasing substrate access and therefore increasing the catalytic rate of the serine/threonine kinase. In this article, we critically review the contributions of in vitro modeling to the current knowledge on LRRK2 G2019S. We also analyze the role of patient-derived cell lines for the identification and validation of therapeutic targets, emphasizing their importance as part of a 3R approach to translational research and personalized medicine." @default.
- W2793879025 created "2018-03-29" @default.
- W2793879025 creator A5032465628 @default.
- W2793879025 creator A5061285720 @default.
- W2793879025 date "2018-07-15" @default.
- W2793879025 modified "2023-09-23" @default.
- W2793879025 title "In Vitro Modeling of Leucine-Rich Repeat Kinase 2 G2019S-Mediated Parkinson's Disease Pathology" @default.
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- W2793879025 cites W1977261578 @default.
- W2793879025 cites W1982396115 @default.
- W2793879025 cites W1983044117 @default.
- W2793879025 cites W1997066981 @default.
- W2793879025 cites W1997163042 @default.
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- W2793879025 cites W2003126320 @default.
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- W2793879025 doi "https://doi.org/10.1089/scd.2017.0286" @default.
- W2793879025 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6044417" @default.
- W2793879025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29402177" @default.
- W2793879025 hasPublicationYear "2018" @default.
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