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- W2793897503 endingPage "295" @default.
- W2793897503 startingPage "281" @default.
- W2793897503 abstract "The mitochondrial network is not only required for the production of energy, essential cofactors and amino acids, but also serves as a signaling hub for innate immune and apoptotic pathways. Multiple mechanisms have evolved to identify and combat mitochondrial dysfunction to maintain the health of the organism. One such pathway is the mitochondrial unfolded protein response (UPRmt), which is regulated by the mitochondrial import efficiency of the transcription factor ATFS-1 in C. elegans and potentially orthologous transcription factors in mammals (ATF4, ATF5, CHOP). Upon mitochondrial dysfunction, import of ATFS-1 into mitochondria is reduced, allowing it to be trafficked to the nucleus where it promotes the expression of genes that promote survival and recovery of the mitochondrial network. Here, we discuss recent findings underlying UPRmt signal transduction and how this adaptive transcriptional response may interact with other mitochondrial stress response pathways." @default.
- W2793897503 created "2018-03-29" @default.
- W2793897503 creator A5014331402 @default.
- W2793897503 creator A5037651606 @default.
- W2793897503 date "2018-02-09" @default.
- W2793897503 modified "2023-10-06" @default.
- W2793897503 title "UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication" @default.
- W2793897503 cites W1526707822 @default.
- W2793897503 cites W1857895180 @default.
- W2793897503 cites W1877873625 @default.
- W2793897503 cites W1919124805 @default.
- W2793897503 cites W1974182237 @default.
- W2793897503 cites W1974522038 @default.
- W2793897503 cites W1976382531 @default.
- W2793897503 cites W1978683461 @default.
- W2793897503 cites W1980438612 @default.
- W2793897503 cites W1980699148 @default.
- W2793897503 cites W1984426737 @default.
- W2793897503 cites W1989108323 @default.
- W2793897503 cites W1990353436 @default.
- W2793897503 cites W1997407309 @default.
- W2793897503 cites W2002364392 @default.
- W2793897503 cites W2003712218 @default.
- W2793897503 cites W2005139390 @default.
- W2793897503 cites W2005853038 @default.
- W2793897503 cites W2007175835 @default.
- W2793897503 cites W2007389227 @default.
- W2793897503 cites W2007997420 @default.
- W2793897503 cites W2009397177 @default.
- W2793897503 cites W2010802040 @default.
- W2793897503 cites W2012861249 @default.
- W2793897503 cites W2013867688 @default.
- W2793897503 cites W2018711046 @default.
- W2793897503 cites W2022487205 @default.
- W2793897503 cites W2023402149 @default.
- W2793897503 cites W2025521110 @default.
- W2793897503 cites W2032022203 @default.
- W2793897503 cites W2035564874 @default.
- W2793897503 cites W2036253883 @default.
- W2793897503 cites W2038324706 @default.
- W2793897503 cites W2038663211 @default.
- W2793897503 cites W2038884694 @default.
- W2793897503 cites W2039603759 @default.
- W2793897503 cites W2041764822 @default.
- W2793897503 cites W2042518400 @default.
- W2793897503 cites W2044897807 @default.
- W2793897503 cites W2046307510 @default.
- W2793897503 cites W2048407491 @default.
- W2793897503 cites W2048551040 @default.
- W2793897503 cites W2048967691 @default.
- W2793897503 cites W2049016912 @default.
- W2793897503 cites W2052889619 @default.
- W2793897503 cites W2053133117 @default.
- W2793897503 cites W2056043482 @default.
- W2793897503 cites W2056959452 @default.
- W2793897503 cites W2057695252 @default.
- W2793897503 cites W2060428113 @default.
- W2793897503 cites W2061983173 @default.
- W2793897503 cites W2063143055 @default.
- W2793897503 cites W2066650294 @default.
- W2793897503 cites W2070427701 @default.
- W2793897503 cites W2071719438 @default.
- W2793897503 cites W2074111563 @default.
- W2793897503 cites W2078644413 @default.
- W2793897503 cites W2080270879 @default.
- W2793897503 cites W2086073886 @default.
- W2793897503 cites W2087592289 @default.
- W2793897503 cites W2087945271 @default.
- W2793897503 cites W2089145020 @default.
- W2793897503 cites W2094684282 @default.
- W2793897503 cites W2095048801 @default.
- W2793897503 cites W2096330540 @default.
- W2793897503 cites W2099377713 @default.
- W2793897503 cites W2103230459 @default.
- W2793897503 cites W2105754268 @default.
- W2793897503 cites W2108326484 @default.
- W2793897503 cites W2108738634 @default.
- W2793897503 cites W2109291482 @default.
- W2793897503 cites W2111976489 @default.
- W2793897503 cites W2115603706 @default.
- W2793897503 cites W2121647203 @default.
- W2793897503 cites W2122341467 @default.
- W2793897503 cites W2125987139 @default.
- W2793897503 cites W2131632095 @default.
- W2793897503 cites W2132820862 @default.
- W2793897503 cites W2134822049 @default.
- W2793897503 cites W2135269921 @default.
- W2793897503 cites W2136272779 @default.
- W2793897503 cites W2136388422 @default.
- W2793897503 cites W2137173138 @default.
- W2793897503 cites W2138707492 @default.
- W2793897503 cites W2138951501 @default.
- W2793897503 cites W2139636031 @default.
- W2793897503 cites W2141327598 @default.
- W2793897503 cites W2142188572 @default.
- W2793897503 cites W2142353558 @default.
- W2793897503 cites W2144944663 @default.
- W2793897503 cites W2146884956 @default.