FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2793935790> ?p ?o ?g. }

• W2793935790 endingPage "1237" @default.
• W2793935790 startingPage "1229" @default.
• W2793935790 abstract "Metastatic spread is responsible for the majority of cancer-associated deaths. The tumour microenvironment, including hypoxia, is a major driver of metastasis. The aim of this study was to investigate the role of the E3 ligase WSB-1 in breast cancer biology in the context of the hypoxic tumour microenvironment, particularly regarding metastatic spread. In this study, WSB-1 expression was evaluated in breast cancer cell lines and patient samples. In silico analyses were used to determine the impact of WSB-1 expression on distant metastasis-free survival (DMFS) in patients, and correlation between WSB1 expression and hypoxia gene expression signatures. The role of WSB-1 on metastasis promotion was evaluated in vitro and in vivo. High WSB1 expression was associated with decreased DMFS in ER-breast cancer and PR-breast cancer patients. Surprisingly, WSB1 expression was not positively correlated with known hypoxic gene expression signatures in patient samples. Our study is the first to show that WSB-1 knockdown led to decreased metastatic potential in breast cancer hormone receptor-negative models in vitro and in vivo. WSB-1 knockdown was associated with decreased metalloproteinase (MMP) activity, vascular endothelial growth factor (VEGF) secretion, and angiogenic potential. Our data suggests that WSB-1 may be an important regulator of aggressive metastatic disease in hormone receptor-negative breast cancer. WSB-1 could therefore represent a novel regulator and therapeutic target for secondary breast cancer in these patients." @default.
• W2793935790 created "2018-03-29" @default.
• W2793935790 creator A5005843546 @default.
• W2793935790 creator A5007808430 @default.
• W2793935790 creator A5011822215 @default.
• W2793935790 creator A5014918178 @default.
• W2793935790 creator A5016333405 @default.
• W2793935790 creator A5017413865 @default.
• W2793935790 creator A5018081801 @default.
• W2793935790 creator A5044365051 @default.
• W2793935790 creator A5049439759 @default.
• W2793935790 creator A5090932417 @default.
• W2793935790 date "2018-03-15" @default.
• W2793935790 modified "2023-10-07" @default.
• W2793935790 title "WSB-1 regulates the metastatic potential of hormone receptor negative breast cancer" @default.
• W2793935790 cites W1523491666 @default.
• W2793935790 cites W1547961512 @default.
• W2793935790 cites W1682474579 @default.
• W2793935790 cites W1757407923 @default.
• W2793935790 cites W1913598225 @default.
• W2793935790 cites W1965815494 @default.
• W2793935790 cites W1992112921 @default.
• W2793935790 cites W2003132649 @default.
• W2793935790 cites W2024675721 @default.
• W2793935790 cites W2035185432 @default.
• W2793935790 cites W2052783640 @default.
• W2793935790 cites W2071143412 @default.
• W2793935790 cites W2074070171 @default.
• W2793935790 cites W2084116712 @default.
• W2793935790 cites W2085934079 @default.
• W2793935790 cites W2091440325 @default.
• W2793935790 cites W2093257411 @default.
• W2793935790 cites W2095783009 @default.
• W2793935790 cites W2110453313 @default.
• W2793935790 cites W2115785123 @default.
• W2793935790 cites W2118655588 @default.
• W2793935790 cites W2120483851 @default.
• W2793935790 cites W2131181464 @default.
• W2793935790 cites W2140092812 @default.
• W2793935790 cites W2141414987 @default.
• W2793935790 cites W2145983041 @default.
• W2793935790 cites W2147649225 @default.
• W2793935790 cites W2148739751 @default.
• W2793935790 cites W2304208958 @default.
• W2793935790 cites W2323751645 @default.
• W2793935790 doi "https://doi.org/10.1038/s41416-018-0056-3" @default.
• W2793935790 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5943535" @default.
• W2793935790 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29540773" @default.
• W2793935790 hasPublicationYear "2018" @default.
• W2793935790 type Work @default.
• W2793935790 sameAs 2793935790 @default.
• W2793935790 citedByCount "15" @default.
• W2793935790 countsByYear W27939357902019 @default.
• W2793935790 countsByYear W27939357902020 @default.
• W2793935790 countsByYear W27939357902021 @default.
• W2793935790 countsByYear W27939357902022 @default.
• W2793935790 countsByYear W27939357902023 @default.
• W2793935790 crossrefType "journal-article" @default.
• W2793935790 hasAuthorship W2793935790A5005843546 @default.
• W2793935790 hasAuthorship W2793935790A5007808430 @default.
• W2793935790 hasAuthorship W2793935790A5011822215 @default.
• W2793935790 hasAuthorship W2793935790A5014918178 @default.
• W2793935790 hasAuthorship W2793935790A5016333405 @default.
• W2793935790 hasAuthorship W2793935790A5017413865 @default.
• W2793935790 hasAuthorship W2793935790A5018081801 @default.
• W2793935790 hasAuthorship W2793935790A5044365051 @default.
• W2793935790 hasAuthorship W2793935790A5049439759 @default.
• W2793935790 hasAuthorship W2793935790A5090932417 @default.
• W2793935790 hasBestOaLocation W27939357901 @default.
• W2793935790 hasConcept C121608353 @default.
• W2793935790 hasConcept C126322002 @default.
• W2793935790 hasConcept C143998085 @default.
• W2793935790 hasConcept C173396325 @default.
• W2793935790 hasConcept C2775930923 @default.
• W2793935790 hasConcept C2779013556 @default.
• W2793935790 hasConcept C502942594 @default.
• W2793935790 hasConcept C530470458 @default.
• W2793935790 hasConcept C54355233 @default.
• W2793935790 hasConcept C71924100 @default.
• W2793935790 hasConcept C81885089 @default.
• W2793935790 hasConcept C86803240 @default.
• W2793935790 hasConceptScore W2793935790C121608353 @default.
• W2793935790 hasConceptScore W2793935790C126322002 @default.
• W2793935790 hasConceptScore W2793935790C143998085 @default.
• W2793935790 hasConceptScore W2793935790C173396325 @default.
• W2793935790 hasConceptScore W2793935790C2775930923 @default.
• W2793935790 hasConceptScore W2793935790C2779013556 @default.
• W2793935790 hasConceptScore W2793935790C502942594 @default.
• W2793935790 hasConceptScore W2793935790C530470458 @default.
• W2793935790 hasConceptScore W2793935790C54355233 @default.
• W2793935790 hasConceptScore W2793935790C71924100 @default.
• W2793935790 hasConceptScore W2793935790C81885089 @default.
• W2793935790 hasConceptScore W2793935790C86803240 @default.
• W2793935790 hasIssue "9" @default.
• W2793935790 hasLocation W27939357901 @default.
• W2793935790 hasLocation W27939357902 @default.
• W2793935790 hasLocation W27939357903 @default.
• W2793935790 hasLocation W27939357904 @default.

• next