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- W2793937219 abstract "Spatiotemporal control of drug delivery is important for a number of medical applications and may be achieved using polymersome nanoparticles (PMs). Wnt signalling is a molecular pathway activated in various physiological processes, including bone repair, that requires precise control of activation. Here, we hypothesise that PMs can be stably loaded with a small molecule Wnt agonist, 6-bromoindirubin-3′-oxime (BIO), and activate Wnt signalling promoting the osteogenic differentiation in human primary bone marrow stromal cells (BMSCs). We showed that BIO-PMs induced a 40% increase in Wnt signaling activation in reporter cell lines without cytotoxicity induced by free BIO. BMSCs incubated with BIO-PMs showed a significant up-regulation of the Wnt target gene AXIN2 (14 ± 4 fold increase, P < 0.001) and a prolonged activation of the osteogenic gene RUNX2. We conclude that BIO-PMs could represent an innovative approach for the controlled activation of Wnt signaling for promoting bone regeneration after fracture." @default.
- W2793937219 created "2018-03-29" @default.
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- W2793937219 date "2018-06-01" @default.
- W2793937219 modified "2023-09-27" @default.
- W2793937219 title "Polymersome nanoparticles for delivery of Wnt-activating small molecules" @default.
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- W2793937219 doi "https://doi.org/10.1016/j.nano.2018.02.014" @default.
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