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- W2793968100 abstract "Abstract We conducted a meta-analysis of genome-wide association studies (GWAS) with ∼16 million genotyped/imputed genetic variants in 62,892 type 2 diabetes (T2D) cases and 596,424 controls of European ancestry. We identified 139 common and 4 rare (minor allele frequency < 0.01) variants associated with T2D, 42 of which (39 common and 3 rare variants) were independent of the known variants. Integration of the gene expression data from blood ( n = 14,115 and 2,765) and other T2D-relevant tissues ( n = up to 385) with the GWAS results identified 33 putative functional genes for T2D, three of which were targeted by approved drugs. A further integration of DNA methylation ( n = 1,980) and epigenomic annotations data highlighted three putative T2D genes ( CAMK1D, TP53INP1 and ATP5G1 ) with plausible regulatory mechanisms whereby a genetic variant exerts an effect on T2D through epigenetic regulation of gene expression. We further found evidence that the T2D-associated loci have been under purifying selection." @default.
- W2793968100 created "2018-03-29" @default.
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- W2793968100 date "2018-03-20" @default.
- W2793968100 modified "2023-10-14" @default.
- W2793968100 title "Novel susceptibility loci and genetic regulation mechanisms for type 2 diabetes" @default.
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