FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2793993491> ?p ?o ?g. }

• W2793993491 abstract "Abstract Intervertebral disc degeneration (IVDD) is one of the key predisposing factors for low back pain. Although the exact mechanism remains unclear, inflammatory response and nucleus pulposus (NP) apoptosis are known to play important roles in this process. Prolactin protects against inflammation-associated chondrocyte apoptosis in arthritis. Based on prior studies, we hypothesized that prolactin might have therapeutic effects on IVDD by inhibiting the apoptosis of degenerative human disc NP cells. An experimental model of IVDD was established in 3-month-old Sprague-Dawley rats by submitting them to percutaneous disc puncture with a 20-gauge needle on levels 7–8 and 8–9 of the coccygeal vertebrae. Then the rats were injected with 20 or 200 ng prolactin on a weekly basis. Radiologic and histologic analyses were performed on days 4, 7, 14, and 28. The expression of prolactin and its receptor was analyzed in human tissue obtained from symptomatic patients undergoing microencoscopy discectomy, or from scoliosis patients undergoing deformity correction surgery. The results showed that intradiscal injection of prolactin maintained disc height and the mean signal intensity of the punctured disc. Histological analysis indicated that prolactin treatment significantly retained the complete structure of the NP and annulus fibrosus compared with the vehicle group. In addition, more collagen II, but fewer collagen I-containing tissues were detected in the prolactin treatment groups compared to the vehicle group. Moreover, low levels of tumor necrosis factor-α, interleukin-1β, cleaved-caspase 3, and TUNEL staining were observed in the prolactin treatment groups. We also demonstrated that prolactin impaired puncture-induced inflammation and cell apoptosis by downregulating activation of the NF-κB pathway. The degenerated NP tissues from patients had decreased expression of prolactin and its receptor, whereas expression was increased in the NP tissues removed from scoliosis patients. These results suggest that prolactin may be a novel therapeutic target for the treatment of IVDD." @default.
• W2793993491 created "2018-03-29" @default.
• W2793993491 creator A5008281212 @default.
• W2793993491 creator A5034111792 @default.
• W2793993491 creator A5042318166 @default.
• W2793993491 creator A5043739630 @default.
• W2793993491 creator A5047406782 @default.
• W2793993491 creator A5049423141 @default.
• W2793993491 creator A5061834808 @default.
• W2793993491 creator A5068866950 @default.
• W2793993491 creator A5074150706 @default.
• W2793993491 creator A5090949814 @default.
• W2793993491 date "2018-01-24" @default.
• W2793993491 modified "2023-10-16" @default.
• W2793993491 title "Prolactin inhibits the progression of intervertebral disc degeneration through inactivation of the NF-κB pathway in rats" @default.
• W2793993491 cites W146499387 @default.
• W2793993491 cites W1533220576 @default.
• W2793993491 cites W1583233550 @default.
• W2793993491 cites W1965830920 @default.
• W2793993491 cites W1976429655 @default.
• W2793993491 cites W1979264581 @default.
• W2793993491 cites W1993449521 @default.
• W2793993491 cites W1995045618 @default.
• W2793993491 cites W1995596985 @default.
• W2793993491 cites W2014595642 @default.
• W2793993491 cites W2014682637 @default.
• W2793993491 cites W2020775698 @default.
• W2793993491 cites W2021449823 @default.
• W2793993491 cites W2030601224 @default.
• W2793993491 cites W2051624587 @default.
• W2793993491 cites W2052078816 @default.
• W2793993491 cites W2053740136 @default.
• W2793993491 cites W2060861339 @default.
• W2793993491 cites W2061387068 @default.
• W2793993491 cites W2064700294 @default.
• W2793993491 cites W2067909000 @default.
• W2793993491 cites W2070353807 @default.
• W2793993491 cites W2072936530 @default.
• W2793993491 cites W2073882423 @default.
• W2793993491 cites W2086605700 @default.
• W2793993491 cites W2087239362 @default.
• W2793993491 cites W2091573615 @default.
• W2793993491 cites W2092798278 @default.
• W2793993491 cites W2095712464 @default.
• W2793993491 cites W2108344016 @default.
• W2793993491 cites W2111608210 @default.
• W2793993491 cites W2113103296 @default.
• W2793993491 cites W2118720568 @default.
• W2793993491 cites W2158088509 @default.
• W2793993491 cites W2166781237 @default.
• W2793993491 cites W2318077830 @default.
• W2793993491 cites W2318430537 @default.
• W2793993491 cites W2429024809 @default.
• W2793993491 cites W2543904698 @default.
• W2793993491 cites W2574819148 @default.
• W2793993491 cites W2591818121 @default.
• W2793993491 cites W34521940 @default.
• W2793993491 doi "https://doi.org/10.1038/s41419-017-0151-z" @default.
• W2793993491 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5833353" @default.
• W2793993491 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29367664" @default.
• W2793993491 hasPublicationYear "2018" @default.
• W2793993491 type Work @default.
• W2793993491 sameAs 2793993491 @default.
• W2793993491 citedByCount "49" @default.
• W2793993491 countsByYear W27939934912018 @default.
• W2793993491 countsByYear W27939934912019 @default.
• W2793993491 countsByYear W27939934912020 @default.
• W2793993491 countsByYear W27939934912021 @default.
• W2793993491 countsByYear W27939934912022 @default.
• W2793993491 countsByYear W27939934912023 @default.
• W2793993491 crossrefType "journal-article" @default.
• W2793993491 hasAuthorship W2793993491A5008281212 @default.
• W2793993491 hasAuthorship W2793993491A5034111792 @default.
• W2793993491 hasAuthorship W2793993491A5042318166 @default.
• W2793993491 hasAuthorship W2793993491A5043739630 @default.
• W2793993491 hasAuthorship W2793993491A5047406782 @default.
• W2793993491 hasAuthorship W2793993491A5049423141 @default.
• W2793993491 hasAuthorship W2793993491A5061834808 @default.
• W2793993491 hasAuthorship W2793993491A5068866950 @default.
• W2793993491 hasAuthorship W2793993491A5074150706 @default.
• W2793993491 hasAuthorship W2793993491A5090949814 @default.
• W2793993491 hasBestOaLocation W27939934911 @default.
• W2793993491 hasConcept C105702510 @default.
• W2793993491 hasConcept C126322002 @default.
• W2793993491 hasConcept C134018914 @default.
• W2793993491 hasConcept C141071460 @default.
• W2793993491 hasConcept C142724271 @default.
• W2793993491 hasConcept C190283241 @default.
• W2793993491 hasConcept C196795494 @default.
• W2793993491 hasConcept C196843134 @default.
• W2793993491 hasConcept C204232928 @default.
• W2793993491 hasConcept C2776133846 @default.
• W2793993491 hasConcept C2776914184 @default.
• W2793993491 hasConcept C2777755357 @default.
• W2793993491 hasConcept C2779064019 @default.
• W2793993491 hasConcept C2780550940 @default.
• W2793993491 hasConcept C2781403057 @default.
• W2793993491 hasConcept C55493867 @default.
• W2793993491 hasConcept C71315377 @default.
• W2793993491 hasConcept C71924100 @default.

• next