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• W2794027585 endingPage "185" @default.
• W2794027585 startingPage "180" @default.
• W2794027585 abstract "Purpose of review This article explores how the interplay between lipid metabolism and thermogenic adipose tissues enables proper physiological adaptation to cold environments in rodents and humans. Recent findings Cold exposure triggers systemic changes in lipid metabolism, which increases fatty acid delivery to brown adipose tissue (BAT) by various routes. Next to fatty acids generated intracellularly by de-novo lipogenesis or by lipolysis at lipid droplets, brown adipocytes utilize fatty acids released by white adipose tissue (WAT) for adaptive thermogenesis. WAT-derived fatty acids are internalized directly by BAT, or indirectly after hepatic conversion to very low-density lipoproteins and acylcarnitines. In the postprandial state, chylomicrons hydrolyzed by lipoprotein lipase – activated specifically in thermogenic adipocytes – are the predominant fatty acid source. Cholesterol-enriched chylomicron remnants and HDL generated by intravascular lipolysis in BAT are cleared more rapidly by the liver, explaining the antiatherogenic effects of BAT activation. Notably, increased cholesterol flux and elevated hepatic synthesis of bile acids under cold exposure further promote BAT-dependent thermogenesis. Summary Although pathways providing fatty acids for activated BAT have been identified, more research is needed to understand the integration of lipid metabolism in BAT, WAT and liver, and to determine the relevance of BAT for human energy metabolism." @default.
• W2794027585 created "2018-03-29" @default.
• W2794027585 creator A5005653232 @default.
• W2794027585 creator A5068757919 @default.
• W2794027585 date "2018-06-01" @default.
• W2794027585 modified "2023-10-16" @default.
• W2794027585 title "Brown adipose tissue and lipid metabolism" @default.
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• W2794027585 doi "https://doi.org/10.1097/mol.0000000000000504" @default.
• W2794027585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29718003" @default.
• W2794027585 hasPublicationYear "2018" @default.
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