Matches in SemOpenAlex for { <https://semopenalex.org/work/W2794033172> ?p ?o ?g. }
- W2794033172 endingPage "35" @default.
- W2794033172 startingPage "25" @default.
- W2794033172 abstract "Cadherin-23 is an atypical member of the cadherin superfamily, with a distinctly long extracellular domain. It has been known to be a part of the tip links of the inner ear mechanosensory hair cells. Several studies have been carried out to understand the role of Cadherin-23 in the hearing mechanism and defects in the CDH23 have been associated with hearing impairment resulting from defective or absence of tip links. Recent studies have highlighted the role of Cadherin-23 in several pathological conditions, including cancer, suggesting the presence of several unknown functions. Initially, it was proposed that Cadherin-23 represents a yet unspecified subtype of Cadherins; however, no other proteins with similar characteristics have been identified, till date. It has a unique cytoplasmic domain that does not bear a β-catenin binding region, but has been demonstrated to mediate cell-cell adhesions. Several protein interacting partners have been identified for Cadherin-23 and the roles of their interactions in various cellular mechanisms are yet to be explored. This review summarizes the characteristics of Cadherin-23 and its roles in several pathologies including cancer." @default.
- W2794033172 created "2018-03-29" @default.
- W2794033172 creator A5050272646 @default.
- W2794033172 creator A5052272163 @default.
- W2794033172 creator A5059136323 @default.
- W2794033172 date "2018-04-01" @default.
- W2794033172 modified "2023-10-17" @default.
- W2794033172 title "The tip link protein Cadherin-23: From Hearing Loss to Cancer" @default.
- W2794033172 cites W1538619419 @default.
- W2794033172 cites W1539369365 @default.
- W2794033172 cites W1540968669 @default.
- W2794033172 cites W1554664283 @default.
- W2794033172 cites W1728437994 @default.
- W2794033172 cites W1916027575 @default.
- W2794033172 cites W1924259850 @default.
- W2794033172 cites W1939621514 @default.
- W2794033172 cites W1966078124 @default.
- W2794033172 cites W1967017521 @default.
- W2794033172 cites W1969826686 @default.
- W2794033172 cites W1971024110 @default.
- W2794033172 cites W1973461409 @default.
- W2794033172 cites W1974205559 @default.
- W2794033172 cites W1978062289 @default.
- W2794033172 cites W1978790584 @default.
- W2794033172 cites W1983601370 @default.
- W2794033172 cites W1984830616 @default.
- W2794033172 cites W1986342632 @default.
- W2794033172 cites W1986561506 @default.
- W2794033172 cites W1987376344 @default.
- W2794033172 cites W1990549525 @default.
- W2794033172 cites W1991193202 @default.
- W2794033172 cites W1995912317 @default.
- W2794033172 cites W1996702954 @default.
- W2794033172 cites W2000809475 @default.
- W2794033172 cites W2009169574 @default.
- W2794033172 cites W2011571192 @default.
- W2794033172 cites W2013932854 @default.
- W2794033172 cites W2016581293 @default.
- W2794033172 cites W2019332518 @default.
- W2794033172 cites W2022087383 @default.
- W2794033172 cites W2024087638 @default.
- W2794033172 cites W2027518405 @default.
- W2794033172 cites W2027763820 @default.
- W2794033172 cites W2029886990 @default.
- W2794033172 cites W2030026256 @default.
- W2794033172 cites W2031573961 @default.
- W2794033172 cites W2032930150 @default.
- W2794033172 cites W2038000805 @default.
- W2794033172 cites W2038502254 @default.
- W2794033172 cites W2042004725 @default.
- W2794033172 cites W2047411145 @default.
- W2794033172 cites W2047841553 @default.
- W2794033172 cites W2048007302 @default.
- W2794033172 cites W2048500450 @default.
- W2794033172 cites W2049458280 @default.
- W2794033172 cites W2049862483 @default.
- W2794033172 cites W2050066553 @default.
- W2794033172 cites W2053698125 @default.
- W2794033172 cites W2053958751 @default.
- W2794033172 cites W2057381471 @default.
- W2794033172 cites W2058214637 @default.
- W2794033172 cites W2059809313 @default.
- W2794033172 cites W2060877976 @default.
- W2794033172 cites W2061128706 @default.
- W2794033172 cites W2065544787 @default.
- W2794033172 cites W2068976379 @default.
- W2794033172 cites W2075772363 @default.
- W2794033172 cites W2076141253 @default.
- W2794033172 cites W2076827782 @default.
- W2794033172 cites W2077284745 @default.
- W2794033172 cites W2078486382 @default.
- W2794033172 cites W2079768191 @default.
- W2794033172 cites W2087429261 @default.
- W2794033172 cites W2089998882 @default.
- W2794033172 cites W2091127227 @default.
- W2794033172 cites W2091542982 @default.
- W2794033172 cites W2092597147 @default.
- W2794033172 cites W2101146365 @default.
- W2794033172 cites W2104439330 @default.
- W2794033172 cites W2104453327 @default.
- W2794033172 cites W2106876831 @default.
- W2794033172 cites W2107976817 @default.
- W2794033172 cites W2108785499 @default.
- W2794033172 cites W2110634912 @default.
- W2794033172 cites W2111072594 @default.
- W2794033172 cites W2111525556 @default.
- W2794033172 cites W2116016749 @default.
- W2794033172 cites W2117933964 @default.
- W2794033172 cites W2118710429 @default.
- W2794033172 cites W2119868169 @default.
- W2794033172 cites W2122077421 @default.
- W2794033172 cites W2122929023 @default.
- W2794033172 cites W2123471705 @default.
- W2794033172 cites W2124278933 @default.
- W2794033172 cites W2125357980 @default.
- W2794033172 cites W2126726821 @default.
- W2794033172 cites W2126867710 @default.
- W2794033172 cites W2130506593 @default.