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- W2794041627 endingPage "225" @default.
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- W2794041627 abstract "C. difficile infection (CDI) is an important healthcare- but also community-associated disease. CDI is considered a public health threat and an economic burden. A major problem is the high rate of recurrences. Besides classical antibiotic treatments, new therapeutic strategies are needed to prevent infection, to treat patients and prevent recurrences. If fecal transplantation has been recommended to treat recurrences, another key approach is to restore immunity against C. difficile and its virulence factors. Here, after a summary concerning the virulence factors, the host immune response against C. difficile and its role in the outcome of disease, we review the different approaches of passive immunotherapies and vaccines developed against CDI. Passive immunization strategies are designed in function of the target antigen, the antibody-based product and its administration route. Similarly, for active immunization strategies, vaccine antigens can target toxins or surface proteins and immunization can be performed by parenteral or mucosal routes. For passive immunization and vaccination as well, we first present immunization assays performed in animal models and second in humans and associated clinical trials. The different studies are presented according to the mode of administration either parenteral or mucosal and the target antigens, either toxins or colonization factors." @default.
- W2794041627 created "2018-03-29" @default.
- W2794041627 creator A5013701069 @default.
- W2794041627 creator A5029157648 @default.
- W2794041627 creator A5070114672 @default.
- W2794041627 date "2018-01-01" @default.
- W2794041627 modified "2023-10-18" @default.
- W2794041627 title "Immunization Strategies Against Clostridium difficile" @default.
- W2794041627 cites W1482857621 @default.
- W2794041627 cites W1701557898 @default.
- W2794041627 cites W1819802590 @default.
- W2794041627 cites W1830796093 @default.
- W2794041627 cites W1884894858 @default.
- W2794041627 cites W1916481354 @default.
- W2794041627 cites W1943657509 @default.
- W2794041627 cites W1946699898 @default.
- W2794041627 cites W1959219531 @default.
- W2794041627 cites W1963566355 @default.
- W2794041627 cites W1964262120 @default.
- W2794041627 cites W1966505731 @default.
- W2794041627 cites W1967079794 @default.
- W2794041627 cites W1972313488 @default.
- W2794041627 cites W1976423919 @default.
- W2794041627 cites W1982134424 @default.
- W2794041627 cites W1982736713 @default.
- W2794041627 cites W1983387742 @default.
- W2794041627 cites W1983496988 @default.
- W2794041627 cites W1987844440 @default.
- W2794041627 cites W1990202319 @default.
- W2794041627 cites W1991951235 @default.
- W2794041627 cites W1995401406 @default.
- W2794041627 cites W1996060794 @default.
- W2794041627 cites W2001150237 @default.
- W2794041627 cites W2006544197 @default.
- W2794041627 cites W2007377453 @default.
- W2794041627 cites W2008319675 @default.
- W2794041627 cites W2010075812 @default.
- W2794041627 cites W2011676944 @default.
- W2794041627 cites W2012035843 @default.
- W2794041627 cites W2015106311 @default.
- W2794041627 cites W2015590215 @default.
- W2794041627 cites W2016667492 @default.
- W2794041627 cites W2018248632 @default.
- W2794041627 cites W2018793707 @default.
- W2794041627 cites W2020864672 @default.
- W2794041627 cites W2022771107 @default.
- W2794041627 cites W2023520005 @default.
- W2794041627 cites W2025024815 @default.
- W2794041627 cites W2025853891 @default.
- W2794041627 cites W2026991426 @default.
- W2794041627 cites W2027566765 @default.
- W2794041627 cites W2030213550 @default.
- W2794041627 cites W2031159012 @default.
- W2794041627 cites W2033506368 @default.
- W2794041627 cites W2040132528 @default.
- W2794041627 cites W2043577263 @default.
- W2794041627 cites W2047204678 @default.
- W2794041627 cites W2048716195 @default.
- W2794041627 cites W2049511418 @default.
- W2794041627 cites W2051113797 @default.
- W2794041627 cites W2052149039 @default.
- W2794041627 cites W2053791899 @default.
- W2794041627 cites W2053996120 @default.
- W2794041627 cites W2054452997 @default.
- W2794041627 cites W2056041704 @default.
- W2794041627 cites W2058983029 @default.
- W2794041627 cites W2060401427 @default.
- W2794041627 cites W2062232226 @default.
- W2794041627 cites W2064172296 @default.
- W2794041627 cites W2065215967 @default.
- W2794041627 cites W2070509101 @default.
- W2794041627 cites W2071054182 @default.
- W2794041627 cites W2077103365 @default.
- W2794041627 cites W2077865765 @default.
- W2794041627 cites W2080751880 @default.
- W2794041627 cites W2081906581 @default.
- W2794041627 cites W2082036392 @default.
- W2794041627 cites W2083669011 @default.
- W2794041627 cites W2086847883 @default.
- W2794041627 cites W2096061034 @default.
- W2794041627 cites W2097455186 @default.
- W2794041627 cites W2102459023 @default.
- W2794041627 cites W2103254493 @default.
- W2794041627 cites W2103898950 @default.
- W2794041627 cites W2106538777 @default.
- W2794041627 cites W2108515151 @default.
- W2794041627 cites W2108975442 @default.
- W2794041627 cites W2109753027 @default.
- W2794041627 cites W2109885351 @default.
- W2794041627 cites W2110384819 @default.
- W2794041627 cites W2112157204 @default.
- W2794041627 cites W2113265101 @default.
- W2794041627 cites W2114318563 @default.
- W2794041627 cites W2115583334 @default.
- W2794041627 cites W2123458607 @default.
- W2794041627 cites W2124604126 @default.
- W2794041627 cites W2127067932 @default.
- W2794041627 cites W2127116475 @default.