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- W2794051838 abstract "The advent of direct acting antivirals is expected to improve the management of Chronic Hepatitis – C (c-HCV). MOSAIC an observational study conducted in 30 countries describes the profile of c-HCV patients and the impact of Interferon (IFN) treatment on Patient Reported Outcomes and outpatient consultations (Table). Consecutive c-HCV patients initiated on IFN-based treatment were followed for 48 weeks. Of 346 invited patients 279 participated; (189 treatment-naïve and 90 treatment-experienced). IFN-treatment was initiated for 55 (20%): DAA+peg-IFN+RBV: 5, peg-IFN+RBV: 19, IFN+RBV: 1, other: 30. Main reasons for not initiating IFN for physicians were: waiting for new options (32%, 13%); tolerability (15%, 7%); contraindications (9%, NA); costs (7%, 1%) and for patients inconvenience (2%); impact on social/family life and work (9%). Demographic characteristics {Mean (SD) [Range]} of the 55 treated patients: Age: 52.1 (10.39) [31–74] yrs; Duration since HCV diagnosis: 10.8 (10.1) [0 – 46] yrs; and 69.1% male. Baseline cirrhosis status was: minimal/no fibrosis: 20(36.4%), bridging fibrosis: 16(29.1%), cirrhosis: 11(20.0%), portal fibrosis: 4(7.3%) and NA: 4(7.3%). Genotype was G1: 34(61.8%), G3: 11(20.0%), G2: 6(10.9%), G6: 2(3.6%) and n = 1 (1.9%) each for G4, G5. Baseline HCV-RNA level was <800,000 IU/ml: 20(36%), > 800,000 IU/ml: 26(47%) x IU/mL, positive by qualitative assay: 5 (9%), NA: 4(7%). Employment decreased from 46% to 33%. Outpatient consultation during treatment was none: 64%; 1: 11%. >=4: 20%. IFN use in c-HCV patients in MOSAIC is low. Patients treated with IFN-containing regimens experience a substantial negative impact on QoL and productivity. Anticipated availability of new IFN-free regimens is the main reason for not initiating treatment with IFN. Change from baseline EOT: End of Treatment; EQ-5D-5L: EuroQol 5; HCV-PRO: Hepatitis C Patient Reported Outcome Instrument; WPAI: Work Productivity and Activity Impairment Questionnaire; WPI: Work Productivity Impairment; AI: Activity Impairment. Change from baseline EOT: End of Treatment; EQ-5D-5L: EuroQol 5; HCV-PRO: Hepatitis C Patient Reported Outcome Instrument; WPAI: Work Productivity and Activity Impairment Questionnaire; WPI: Work Productivity Impairment; AI: Activity Impairment. Abbvie Corporation" @default.
- W2794051838 created "2018-03-29" @default.
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- W2794051838 date "2018-02-01" @default.
- W2794051838 modified "2023-09-26" @default.
- W2794051838 title "A223 MOSAIC: AN INTERNATIONAL MULTICENTRE PROSPECTIVE OBSERVATIONAL STUDY TO EVALUATE THE EPIDEMIOLOGY, HUMANISTIC AND ECONOMIC OUTCOMES OF TREATMENT FOR CHRONIC HEPATITIS C VIRUS (HCV)" @default.
- W2794051838 doi "https://doi.org/10.1093/jcag/gwy008.224" @default.
- W2794051838 hasPublicationYear "2018" @default.
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