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• W2794078524 endingPage "77" @default.
• W2794078524 startingPage "57" @default.
• W2794078524 abstract "This review presents the results of experimental studies on the effects of hyperthermia, at a temperature of 40–45 °C, in normal and tumor tissues. These results show that there is a strong rationale for using hyperthermia in addition to radiotherapy and/or chemotherapy in patients with cancer. The following study results are summarized. Hyperthermia has cell killing effects which specifically occur in tumor regions with hypoxia and low pH. In well perfused and well oxygenated tissues, cell damage is usually not observed at temperatures of up to 43 °C. This cell killing effect of hyperthermia is complementary to the effects of radiotherapy and chemotherapy, which treatment modalities are less effective in hypoxic or insufficiently perfused areas. In combination with radio- or chemotherapy, hyperthermia further has sensitizing effects, partly through an increase in blood flow. An important feature in radiosensitization is the inhibition of DNA repair pathways. Radiosensitizing is stronger in tumor tissue than in normal tissue when radiation and hyperthermia are given with a time interval, leading to therapeutic gain. The interaction with various drugs is related to changes in pharmacokinetics, enhancement of drug accumulation and a decrease in intracellular detoxification and damage repair. It was also observed that hyperthermia can overcome chemoresistance associated with multidrug resistance, by influencing transmembrane transport, metabolism, and the functioning of involved proteins. The effects of hyperthermia are stronger with higher temperatures and longer exposure times. Treatment with hyperthermia induces heat shock proteins (HSP’s). These may lead to thermotolerance to the next treatment when that is applied too soon. On the other hand it was found that HSP’s induce an antitumor immune response which may further add to the therapeutic effect. A stimulating effect of hyperthermia on the development of metastases could not be demonstrated in most studies. Studies with drugs in thermosensitive liposomes show that the uptake of drugs in tumor tissues can be largely enhanced. Further, it has been shown that hyperthermia considerably increases the sensitivity of cancer stem cells to radiotherapy and chemotherapy. Sofar, there is limited experience with the combination of hyperthermia and targeted agents. Nanoparticles which can be used for local heat treatment and local drug delivery are under investigation." @default.
• W2794078524 created "2018-03-29" @default.
• W2794078524 creator A5068112534 @default.
• W2794078524 creator A5054425573 @default.
• W2794078524 date "2018-02-13" @default.
• W2794078524 modified "2023-09-24" @default.
• W2794078524 title "Experimental Basis for the Use of Hyperthermia in Oncology" @default.
• W2794078524 cites W173117018 @default.
• W2794078524 cites W1833976733 @default.
• W2794078524 cites W19308927 @default.
• W2794078524 cites W1952811152 @default.
• W2794078524 cites W1963639913 @default.
• W2794078524 cites W1966000016 @default.
• W2794078524 cites W1969755253 @default.
• W2794078524 cites W1970873025 @default.
• W2794078524 cites W1971732025 @default.
• W2794078524 cites W1972905909 @default.
• W2794078524 cites W1977134980 @default.
• W2794078524 cites W1978847021 @default.
• W2794078524 cites W1979378419 @default.
• W2794078524 cites W1981290705 @default.
• W2794078524 cites W1982507764 @default.
• W2794078524 cites W1983055432 @default.
• W2794078524 cites W1984710585 @default.
• W2794078524 cites W1985186952 @default.
• W2794078524 cites W1985507036 @default.
• W2794078524 cites W1987089893 @default.
• W2794078524 cites W1987142444 @default.
• W2794078524 cites W1990489521 @default.
• W2794078524 cites W1997522053 @default.
• W2794078524 cites W1998331014 @default.
• W2794078524 cites W1998886157 @default.
• W2794078524 cites W2002618474 @default.
• W2794078524 cites W2005120120 @default.
• W2794078524 cites W2005152238 @default.
• W2794078524 cites W2005804168 @default.
• W2794078524 cites W2011778255 @default.
• W2794078524 cites W2014628113 @default.
• W2794078524 cites W2015055491 @default.
• W2794078524 cites W2023746083 @default.
• W2794078524 cites W2023806727 @default.
• W2794078524 cites W2025083544 @default.
• W2794078524 cites W2025296922 @default.
• W2794078524 cites W2025537895 @default.
• W2794078524 cites W2025547067 @default.
• W2794078524 cites W2027690665 @default.
• W2794078524 cites W2029208951 @default.
• W2794078524 cites W2031696462 @default.
• W2794078524 cites W2032111162 @default.
• W2794078524 cites W2032668962 @default.
• W2794078524 cites W2032739238 @default.
• W2794078524 cites W2033671499 @default.
• W2794078524 cites W2034578526 @default.
• W2794078524 cites W2035887662 @default.
• W2794078524 cites W2037588242 @default.
• W2794078524 cites W2037653557 @default.
• W2794078524 cites W2043916264 @default.
• W2794078524 cites W2044565540 @default.
• W2794078524 cites W2044905529 @default.
• W2794078524 cites W2047172303 @default.
• W2794078524 cites W2052939117 @default.
• W2794078524 cites W2053004997 @default.
• W2794078524 cites W2053984213 @default.
• W2794078524 cites W2063356208 @default.
• W2794078524 cites W2064828580 @default.
• W2794078524 cites W2066483982 @default.
• W2794078524 cites W2067283691 @default.
• W2794078524 cites W2071159809 @default.
• W2794078524 cites W2071503082 @default.
• W2794078524 cites W2073074450 @default.
• W2794078524 cites W2084130306 @default.
• W2794078524 cites W2084872528 @default.
• W2794078524 cites W2086751539 @default.
• W2794078524 cites W2090395289 @default.
• W2794078524 cites W2098287633 @default.
• W2794078524 cites W2098460586 @default.
• W2794078524 cites W2105644599 @default.
• W2794078524 cites W2107162363 @default.
• W2794078524 cites W2109375155 @default.
• W2794078524 cites W2113591972 @default.
• W2794078524 cites W2118164405 @default.
• W2794078524 cites W2125007784 @default.
• W2794078524 cites W2125941146 @default.
• W2794078524 cites W2126759640 @default.
• W2794078524 cites W2128668604 @default.
• W2794078524 cites W2130070907 @default.
• W2794078524 cites W2131850727 @default.
• W2794078524 cites W2139349831 @default.
• W2794078524 cites W2144374945 @default.
• W2794078524 cites W2148646630 @default.
• W2794078524 cites W2149784089 @default.
• W2794078524 cites W2151948621 @default.
• W2794078524 cites W2157725469 @default.
• W2794078524 cites W2158304149 @default.
• W2794078524 cites W2160310393 @default.
• W2794078524 cites W2161555945 @default.
• W2794078524 cites W2164987676 @default.
• W2794078524 cites W2165200432 @default.

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