Matches in SemOpenAlex for { <https://semopenalex.org/work/W2794108370> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2794108370 endingPage "130" @default.
- W2794108370 startingPage "130" @default.
- W2794108370 abstract "Molecular complexation is a strategy used to modify the physicochemical or biopharmaceutical properties of an active pharmaceutical ingredient. Solvent assisted grinding is a common method used to obtain solid complexes in the form of cocrystals. Lidocaine is a drug used as an anesthetic and for the treatment of chronic pain, which bears in its chemical structure an amide functional group able to form hydrogen bonds. Polyphenols are used as cocrystal coformers due to their ability to form O–H···X (X = O, N) hydrogen bond interactions. The objective of this study was to exploit the ability of phloroglucinol to form molecular complexes with lidocaine by liquid assisted grinding. The formation of the complex was confirmed by the shift of the O–H and C=O stretching bands in the IR spectra of the polycrystalline ground powders, suggesting the formation of O–H···O=C hydrogen bonds. Hydration of the complexes also was confirmed by IR spectroscopy and by powder X-ray diffraction. The molecular structure was determined by single crystal X-ray diffraction." @default.
- W2794108370 created "2018-03-29" @default.
- W2794108370 creator A5000470791 @default.
- W2794108370 creator A5012705041 @default.
- W2794108370 creator A5021327373 @default.
- W2794108370 creator A5035392295 @default.
- W2794108370 creator A5055599876 @default.
- W2794108370 date "2018-03-09" @default.
- W2794108370 modified "2023-10-18" @default.
- W2794108370 title "Mechanochemical Synthesis and Crystal Structure of the Lidocaine-Phloroglucinol Hydrate 1:1:1 Complex" @default.
- W2794108370 cites W1194529981 @default.
- W2794108370 cites W1996590045 @default.
- W2794108370 cites W2005196345 @default.
- W2794108370 cites W2010041386 @default.
- W2794108370 cites W2033264118 @default.
- W2794108370 cites W2037669981 @default.
- W2794108370 cites W2038863763 @default.
- W2794108370 cites W2076818145 @default.
- W2794108370 cites W2080937409 @default.
- W2794108370 cites W2115767512 @default.
- W2794108370 cites W2128868542 @default.
- W2794108370 cites W2131350133 @default.
- W2794108370 cites W2142802964 @default.
- W2794108370 cites W2144120563 @default.
- W2794108370 cites W2144332006 @default.
- W2794108370 cites W2312497560 @default.
- W2794108370 cites W2318047941 @default.
- W2794108370 cites W2318985199 @default.
- W2794108370 cites W2328901473 @default.
- W2794108370 cites W2346538334 @default.
- W2794108370 cites W2565783413 @default.
- W2794108370 cites W2599801457 @default.
- W2794108370 cites W2605735623 @default.
- W2794108370 cites W4244455383 @default.
- W2794108370 doi "https://doi.org/10.3390/cryst8030130" @default.
- W2794108370 hasPublicationYear "2018" @default.
- W2794108370 type Work @default.
- W2794108370 sameAs 2794108370 @default.
- W2794108370 citedByCount "8" @default.
- W2794108370 countsByYear W27941083702018 @default.
- W2794108370 countsByYear W27941083702020 @default.
- W2794108370 countsByYear W27941083702021 @default.
- W2794108370 countsByYear W27941083702022 @default.
- W2794108370 countsByYear W27941083702023 @default.
- W2794108370 crossrefType "journal-article" @default.
- W2794108370 hasAuthorship W2794108370A5000470791 @default.
- W2794108370 hasAuthorship W2794108370A5012705041 @default.
- W2794108370 hasAuthorship W2794108370A5021327373 @default.
- W2794108370 hasAuthorship W2794108370A5035392295 @default.
- W2794108370 hasAuthorship W2794108370A5055599876 @default.
- W2794108370 hasBestOaLocation W27941083701 @default.
- W2794108370 hasConcept C100687433 @default.
- W2794108370 hasConcept C112887158 @default.
- W2794108370 hasConcept C137637335 @default.
- W2794108370 hasConcept C153642686 @default.
- W2794108370 hasConcept C178790620 @default.
- W2794108370 hasConcept C185039092 @default.
- W2794108370 hasConcept C185592680 @default.
- W2794108370 hasConcept C2778626014 @default.
- W2794108370 hasConcept C2781060337 @default.
- W2794108370 hasConcept C32909587 @default.
- W2794108370 hasConcept C508816927 @default.
- W2794108370 hasConcept C8010536 @default.
- W2794108370 hasConceptScore W2794108370C100687433 @default.
- W2794108370 hasConceptScore W2794108370C112887158 @default.
- W2794108370 hasConceptScore W2794108370C137637335 @default.
- W2794108370 hasConceptScore W2794108370C153642686 @default.
- W2794108370 hasConceptScore W2794108370C178790620 @default.
- W2794108370 hasConceptScore W2794108370C185039092 @default.
- W2794108370 hasConceptScore W2794108370C185592680 @default.
- W2794108370 hasConceptScore W2794108370C2778626014 @default.
- W2794108370 hasConceptScore W2794108370C2781060337 @default.
- W2794108370 hasConceptScore W2794108370C32909587 @default.
- W2794108370 hasConceptScore W2794108370C508816927 @default.
- W2794108370 hasConceptScore W2794108370C8010536 @default.
- W2794108370 hasIssue "3" @default.
- W2794108370 hasLocation W27941083701 @default.
- W2794108370 hasOpenAccess W2794108370 @default.
- W2794108370 hasPrimaryLocation W27941083701 @default.
- W2794108370 hasRelatedWork W1831733847 @default.
- W2794108370 hasRelatedWork W1968389100 @default.
- W2794108370 hasRelatedWork W1989515978 @default.
- W2794108370 hasRelatedWork W1994218617 @default.
- W2794108370 hasRelatedWork W1999011562 @default.
- W2794108370 hasRelatedWork W2030334851 @default.
- W2794108370 hasRelatedWork W2079346183 @default.
- W2794108370 hasRelatedWork W2315087761 @default.
- W2794108370 hasRelatedWork W2902603126 @default.
- W2794108370 hasRelatedWork W3094816455 @default.
- W2794108370 hasVolume "8" @default.
- W2794108370 isParatext "false" @default.
- W2794108370 isRetracted "false" @default.
- W2794108370 magId "2794108370" @default.
- W2794108370 workType "article" @default.