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• W2794112818 abstract "The maintenance of genomic stability in the face of endogenous and exogenous sources of DNA damage requires a robust and comprehensive cellular response. This response, appropriately deemed the DNA damage response (DDR), facilitates changes in the cellular environment promoting and coordinating cell cycle arrest, DNA repair, and cell death in cases of extreme or prolonged genomic insult. Initiation of DDR is primarily elicited by three members of the PIKK (phosphatidylinositol-3-kinase-like kinase) family: ATM (ataxia-telangiectasia mutated), ATR (ataxia-telangiectasia and Rad3-related), and DNA-PK (DNA-dependent protein kinase). While all three are required for proper genomic maintenance, DNA-PK lacks the capacity to elicit many of the effects induced by ATM or ATR. For this reason, DNA damage signaling (DDS) generally is considered to occur mainly through ATM and ATR. Recent studies, however, have implicated that DNA-PK can regulate DDS through hindrance of ATM-DDS, giving rise to an evolving view in which all three PIKK family members are essential for regulation of DDS, but not its initiation. This chapter presents a discussion of the signaling within human systems induced by DNA damage as well as an overview of the roles of DDS in promoting DDR-mediated cell cycle arrest, DNA damage repair, and changes to other cellular processes. Within this context, the roles of DDR in current and proposed chemotherapeutics will be explored." @default.
• W2794112818 created "2018-03-29" @default.
• W2794112818 creator A5050784785 @default.
• W2794112818 creator A5089917952 @default.
• W2794112818 creator A5090868034 @default.
• W2794112818 date "2017-11-17" @default.
• W2794112818 modified "2023-09-27" @default.
• W2794112818 title "DNA Damage: Cellular Responses, Repair, and Cancer Treatment" @default.
• W2794112818 cites W1480741751 @default.
• W2794112818 cites W1875936957 @default.
• W2794112818 cites W1942110646 @default.
• W2794112818 cites W1951946904 @default.
• W2794112818 cites W1963581476 @default.
• W2794112818 cites W1964719993 @default.
• W2794112818 cites W1965086052 @default.
• W2794112818 cites W1966098047 @default.
• W2794112818 cites W1966886904 @default.
• W2794112818 cites W1967049460 @default.
• W2794112818 cites W1968319491 @default.
• W2794112818 cites W1968552183 @default.
• W2794112818 cites W1970072945 @default.
• W2794112818 cites W1974327959 @default.
• W2794112818 cites W1974706661 @default.
• W2794112818 cites W1977317997 @default.
• W2794112818 cites W1979028355 @default.
• W2794112818 cites W1979385111 @default.
• W2794112818 cites W1980676055 @default.
• W2794112818 cites W1984152805 @default.
• W2794112818 cites W1984201646 @default.
• W2794112818 cites W1987211450 @default.
• W2794112818 cites W1992860902 @default.
• W2794112818 cites W1993111811 @default.
• W2794112818 cites W1996046994 @default.
• W2794112818 cites W2001055161 @default.
• W2794112818 cites W2002936090 @default.
• W2794112818 cites W2005615310 @default.
• W2794112818 cites W2009779043 @default.
• W2794112818 cites W2012064508 @default.
• W2794112818 cites W2017541181 @default.
• W2794112818 cites W2018458310 @default.
• W2794112818 cites W2019595755 @default.
• W2794112818 cites W2020903791 @default.
• W2794112818 cites W2022811243 @default.
• W2794112818 cites W2025346084 @default.
• W2794112818 cites W2028767678 @default.
• W2794112818 cites W2029304297 @default.
• W2794112818 cites W2032142624 @default.
• W2794112818 cites W2035175399 @default.
• W2794112818 cites W2037550202 @default.
• W2794112818 cites W2038007890 @default.
• W2794112818 cites W2038078790 @default.
• W2794112818 cites W2038144270 @default.
• W2794112818 cites W2038180878 @default.
• W2794112818 cites W2041552603 @default.
• W2794112818 cites W2043776245 @default.
• W2794112818 cites W2043895957 @default.
• W2794112818 cites W2046083330 @default.
• W2794112818 cites W2046175921 @default.
• W2794112818 cites W2049812251 @default.
• W2794112818 cites W2050142910 @default.
• W2794112818 cites W2050164541 @default.
• W2794112818 cites W2054512985 @default.
• W2794112818 cites W2057834096 @default.
• W2794112818 cites W2058831361 @default.
• W2794112818 cites W2061089834 @default.
• W2794112818 cites W2061197983 @default.
• W2794112818 cites W2062568878 @default.
• W2794112818 cites W2065588235 @default.
• W2794112818 cites W2065761939 @default.
• W2794112818 cites W2067395145 @default.
• W2794112818 cites W2070821144 @default.
• W2794112818 cites W2072806146 @default.
• W2794112818 cites W2073148121 @default.
• W2794112818 cites W2075707444 @default.
• W2794112818 cites W2076314401 @default.
• W2794112818 cites W2077436902 @default.
• W2794112818 cites W2078710083 @default.
• W2794112818 cites W2081694922 @default.
• W2794112818 cites W2082447947 @default.
• W2794112818 cites W2082981258 @default.
• W2794112818 cites W2083874142 @default.
• W2794112818 cites W2084745121 @default.
• W2794112818 cites W2086465650 @default.
• W2794112818 cites W2086688857 @default.
• W2794112818 cites W2089126898 @default.
• W2794112818 cites W2090408878 @default.
• W2794112818 cites W2094395583 @default.
• W2794112818 cites W2096815117 @default.
• W2794112818 cites W2097124161 @default.
• W2794112818 cites W2097165440 @default.
• W2794112818 cites W2098577031 @default.
• W2794112818 cites W2098702755 @default.
• W2794112818 cites W2099113454 @default.
• W2794112818 cites W2102003117 @default.
• W2794112818 cites W2102107922 @default.
• W2794112818 cites W2102752109 @default.
• W2794112818 cites W2103451229 @default.
• W2794112818 cites W2103596198 @default.

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