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• W2794114920 startingPage "303" @default.
• W2794114920 abstract "The sirtuin SIRT1 is a highly conserved nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylase known to have protective effects against a wide range of neurological disorders. In the present study, we discovered that C57BL/6 mice fed a long-term diet supplemented with high-dose resveratrol exhibited increased cochlear SIRT1 activity and presented a better recovery of hearing and less loss of hair cells after intense noise exposure compared with those fed a standard chew. Moreover, resveratrol attenuated cochlear SIRT1 decrease and reduced oxidative stress in the cochlea after noise exposure. These results suggest a considerable therapeutic potential of resveratrol for the treatment of noise-induced hearing loss." @default.
• W2794114920 created "2018-03-29" @default.
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• W2794114920 date "2017-01-01" @default.
• W2794114920 modified "2023-10-14" @default.
• W2794114920 title "Resveratrol Promotes Recovery of Hearing following Intense Noise Exposure by Enhancing Cochlear SIRT1 Activity" @default.
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• W2794114920 doi "https://doi.org/10.1159/000485312" @default.
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