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- W2794137041 endingPage "433" @default.
- W2794137041 startingPage "417" @default.
- W2794137041 abstract "The success of immune checkpoint blockade in patients with a wide variety of malignancies has changed the treatment paradigm in oncology. However, combination therapies with immune checkpoint blockade will be needed to overcome resistance and broaden the clinical utility of immunotherapy. Here we discuss a framework for rationally designing combination therapy strategies based on enhancing major discriminatory functions of the immune system that are corrupted by cancer-namely, antigenicity, adjuvanticity, and homeostatic feedback inhibition. We review recent advances on how conventional genotoxic cancer therapies, molecularly targeted therapies, epigenetic agents, and immune checkpoint inhibitors can restore these discriminatory functions. Potential barriers that can impede response despite combination therapy are also discussed." @default.
- W2794137041 created "2018-03-29" @default.
- W2794137041 creator A5082058259 @default.
- W2794137041 creator A5090259280 @default.
- W2794137041 date "2018-03-01" @default.
- W2794137041 modified "2023-10-11" @default.
- W2794137041 title "Combination Cancer Therapy with Immune Checkpoint Blockade: Mechanisms and Strategies" @default.
- W2794137041 cites W1498931318 @default.
- W2794137041 cites W1561349380 @default.
- W2794137041 cites W1572739876 @default.
- W2794137041 cites W1614021468 @default.
- W2794137041 cites W1781506009 @default.
- W2794137041 cites W1898887656 @default.
- W2794137041 cites W1905278501 @default.
- W2794137041 cites W1911271782 @default.
- W2794137041 cites W1943227576 @default.
- W2794137041 cites W1953890763 @default.
- W2794137041 cites W1955548161 @default.
- W2794137041 cites W1964081206 @default.
- W2794137041 cites W1980137951 @default.
- W2794137041 cites W1986320576 @default.
- W2794137041 cites W1992636747 @default.
- W2794137041 cites W1994826332 @default.
- W2794137041 cites W1995997868 @default.
- W2794137041 cites W1996863944 @default.
- W2794137041 cites W1997944395 @default.
- W2794137041 cites W1999020268 @default.
- W2794137041 cites W2004651892 @default.
- W2794137041 cites W2011458181 @default.
- W2794137041 cites W2015879727 @default.
- W2794137041 cites W2016749309 @default.
- W2794137041 cites W2017634591 @default.
- W2794137041 cites W2024556668 @default.
- W2794137041 cites W2027284694 @default.
- W2794137041 cites W2028107828 @default.
- W2794137041 cites W2032166347 @default.
- W2794137041 cites W2032523448 @default.
- W2794137041 cites W2037457284 @default.
- W2794137041 cites W2039123767 @default.
- W2794137041 cites W2042433863 @default.
- W2794137041 cites W2042619042 @default.
- W2794137041 cites W2042687451 @default.
- W2794137041 cites W2044748328 @default.
- W2794137041 cites W2044757050 @default.
- W2794137041 cites W2045963664 @default.
- W2794137041 cites W2047726865 @default.
- W2794137041 cites W2049553585 @default.
- W2794137041 cites W2049868800 @default.
- W2794137041 cites W2057893793 @default.
- W2794137041 cites W2061593724 @default.
- W2794137041 cites W2062608631 @default.
- W2794137041 cites W2066013154 @default.
- W2794137041 cites W2066471812 @default.
- W2794137041 cites W2070131223 @default.
- W2794137041 cites W2071588926 @default.
- W2794137041 cites W2072823316 @default.
- W2794137041 cites W2088230924 @default.
- W2794137041 cites W2101327682 @default.
- W2794137041 cites W2101910308 @default.
- W2794137041 cites W2103021272 @default.
- W2794137041 cites W2104885590 @default.
- W2794137041 cites W2104966044 @default.
- W2794137041 cites W2107079238 @default.
- W2794137041 cites W2107598346 @default.
- W2794137041 cites W2108789863 @default.
- W2794137041 cites W2109485845 @default.
- W2794137041 cites W2110305039 @default.
- W2794137041 cites W2111220263 @default.
- W2794137041 cites W2113172016 @default.
- W2794137041 cites W2114101532 @default.
- W2794137041 cites W2114173013 @default.
- W2794137041 cites W2115161796 @default.
- W2794137041 cites W2115741810 @default.
- W2794137041 cites W2123469465 @default.
- W2794137041 cites W2124292154 @default.
- W2794137041 cites W2124427232 @default.
- W2794137041 cites W2127733313 @default.
- W2794137041 cites W2128758225 @default.
- W2794137041 cites W2132413371 @default.
- W2794137041 cites W2135660738 @default.
- W2794137041 cites W2136399042 @default.
- W2794137041 cites W2136731993 @default.
- W2794137041 cites W2137289789 @default.
- W2794137041 cites W2141476381 @default.
- W2794137041 cites W2142471137 @default.
- W2794137041 cites W2142530756 @default.
- W2794137041 cites W2143772132 @default.
- W2794137041 cites W2148482462 @default.
- W2794137041 cites W2166662937 @default.
- W2794137041 cites W2166932124 @default.
- W2794137041 cites W2167048802 @default.
- W2794137041 cites W2172170289 @default.
- W2794137041 cites W2173565120 @default.
- W2794137041 cites W2207677213 @default.
- W2794137041 cites W2210453860 @default.
- W2794137041 cites W2220279767 @default.
- W2794137041 cites W2228117528 @default.
- W2794137041 cites W2252550602 @default.