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• W2794144657 abstract "// Li Wang 1 , Yujuan Zhang 1 , Kangdong Liu 1, 2, 3, 4 , Hanyong Chen 5 , Ran Yang 1 , Xiaoli Ma 1, 2 , Hong-Gyum Kim 1 , Ann M. Bode 5 , Dong Joon Kim 1 and Zigang Dong 1, 5 1 China–US (Henan) Hormel Cancer Institute, Henan, China 2 The Pathophysiology Department, The School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China 3 The Affiliated Cancer Hospital, Zhengzhou University, Zhengzhou, Henan, China 4 The Collaborative Innovation Center of Henan Province for Cancer Chemoprevention, Zhengzhou, China 5 The Hormel Institute, University of Minnesota, Austin, MN, USA Correspondence to: Dong Joon Kim, email: djkim@hci-cn.org Zigang Dong, email: zgdong@hi.umn.edu Keywords: carnosol; RSK2; gastric cancer; patient-derived tumor xenograft Received: September 22, 2017     Accepted: January 09, 2018     Epub: February 06, 2018     Published: September 28, 2018 ABSTRACT Carnosol is a phenolic diterpene that is isolated from rosemary, sage, and oregano. It has been reported to possess anti-oxidant, anti-inflammatory, and anti-cancer properties. However, the molecular mechanism of carnosol’s activity against gastric cancer has not been investigated. Herein, we report that carnosol is an RSK2 inhibitor that attenuates gastric cancer growth. Carnosol reduced anchorage-dependent and -independent gastric cancer growth by inhibiting the RSKs-CREB signaling pathway. The results of in vitro screening and cell-based assays indicated that carnosol represses RSK2 activity and its downstream signaling. Carnosol increased the G2/M phase and decreased S phase cell cycle and also induced apoptosis through the activation of caspases 9 and 7 and inhibition of Bcl-xL expression. Notably, oral administration of carnosol suppressed patient-derived gastric tumor growth in an in vivo mouse model. Our findings suggest that carnosol is an RSK2 inhibitor that could be useful for treating gastric cancer." @default.
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• W2794144657 date "2018-02-06" @default.
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• W2794144657 title "Carnosol suppresses patient-derived gastric tumor growth by targeting RSK2" @default.
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• W2794144657 doi "https://doi.org/10.18632/oncotarget.24409" @default.
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