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- W2794149082 startingPage "265967" @default.
- W2794149082 abstract "The apicoplast is an essential plastid organelle in malaria parasites (Plasmodium spp.) and a validated anti-parasitic target. A major hurdle to uncovering cryptic apicoplast pathways required for malaria pathogenesis is the lack of an organellar proteome. Here we combine proximity biotinylation-based proteomics (BioID) and a new machine learning algorithm to generate the first high-confidence apicoplast proteome consisting of 346 proteins. Critically, the accuracy of this proteome significantly outperforms previous prediction-based methods. Half of identified proteins have unknown function, and 77% are predicted to be important for normal blood-stage growth. We validate the apicoplast localization of a subset of novel proteins and show that an ATP-binding cassette protein ABCF1 is essential for blood-stage survival and plays a previously unknown role in apicoplast biogenesis. These findings indicate critical organellar functions for newly-discovered apicoplast proteins. The apicoplast proteome will be an important resource for elucidating unique pathways and prioritizing antimalarial drug targets." @default.
- W2794149082 created "2018-03-29" @default.
- W2794149082 creator A5005370974 @default.
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- W2794149082 creator A5086820290 @default.
- W2794149082 creator A5089405717 @default.
- W2794149082 date "2018-02-14" @default.
- W2794149082 modified "2023-10-09" @default.
- W2794149082 title "The proteome of the malaria plastid organelle, a key anti-parasitic target" @default.
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- W2794149082 hasPublicationYear "2018" @default.