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- W2794187440 abstract "A liquid chromatography-tandem mass spectrometry method was developed and validated for simultaneous determination of six bioactive constituents including vitexin, orientin, isoorientin, 2″-O-β-d-xylopyranosyl isoorientin, 2″-O-β-d-xylopyranosyl isovitexin, and 6-C-l-α-arabipyranosyl vitexin in rats’ various tissues using isoquercitrin as the internal standard. Biological samples were pretreated by protein precipitation with acetonitrile. Chromatographic separation was carried out on a C18 column with a gradient mobile phase consisting of acetonitrile and 0.1% aqueous formic acid. All analytes and internal standard were quantitated through electrospray ionization in negative ion selected reaction monitoring mode. The mass transitions were as follows: m/z 431 → 311 for vitexin, m/z 447 → 327 for orientin or isoorientin, m/z 579 → 459 for 2″-O-β-d-xylopyranosyl isoorientin, m/z 563 → 293 for 2″-O-β-d-xylopyranosyl isovitexin, m/z 563 → 353 for 6-C-l-α-arabipyranosyl vitexin, and m/z 463 → 300 for the internal standard, respectively. The lower limits of quantification for the six analytes in different tissue homogenates were 0.8–2.2 ng/ml. The validated assay was successfully applied to a tissue distribution study of the six components in rats after intravenous administration of total flavonoids of Scorzonera austriaca Willd; Asteraceae. The results of the tissue distribution study showed that the high concentrations of six components were mainly in the kidney." @default.
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- W2794187440 date "2018-03-01" @default.
- W2794187440 modified "2023-10-07" @default.
- W2794187440 title "Simultaneous determination of six bioactive components of total flavonoids of Scorzonera austriaca in rat tissues by LC-MS/MS: application to a tissue distribution study" @default.
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- W2794187440 doi "https://doi.org/10.1016/j.bjp.2018.01.004" @default.
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