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- W2794226421 abstract "Chronic obstructive pulmonary disease (COPD) is a diverse respiratory disease characterised by bronchiolitis, small airway obstruction, and emphysema. Innate immune cells play a pivotal role in the disease's progression, and in particular, lung macrophages exploit their prevalence and strategic localisation to orchestrate immune responses. To date, alveolar and interstitial resident macrophages as well as blood monocytes have been described in the lungs of patients with COPD contributing to disease pathology by changes in their functional repertoire. In this review, we summarise recent evidence from human studies and work with animal models of COPD with regard to altered functions of each of these myeloid cell populations. We primarily focus on the dysregulated capacity of alveolar macrophages to secrete proinflammatory mediators and proteases, induce oxidative stress, engulf microbes and apoptotic cells, and express surface and intracellular markers in patients with COPD. In addition, we discuss the differences in the responses between alveolar macrophages and interstitial macrophages/monocytes in the disease and propose how the field should advance to better understand the implications of lung macrophage functions in COPD." @default.
- W2794226421 created "2018-03-29" @default.
- W2794226421 creator A5003349585 @default.
- W2794226421 creator A5029880074 @default.
- W2794226421 creator A5049008492 @default.
- W2794226421 creator A5059931392 @default.
- W2794226421 creator A5082416154 @default.
- W2794226421 date "2018-01-01" @default.
- W2794226421 modified "2023-10-16" @default.
- W2794226421 title "Dysregulated Functions of Lung Macrophage Populations in COPD" @default.
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