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- W2794234037 endingPage "139" @default.
- W2794234037 startingPage "127" @default.
- W2794234037 abstract "Partner-Switching Systems (PSS) are widespread regulatory systems, each comprising a kinase-anti-σ, a phosphorylatable anti-σ antagonist and a phosphatase module. The anti-σ domain quickly sequesters or delivers the target σ factor according to the phosphorylation state of the anti-σ antagonist induced by environmental signals. The PSS components are proteins alone or merged to other domains probably to adapt to the input signals. PSS are involved in major cellular processes including stress response, sporulation, biofilm formation and pathogenesis. Surprisingly, the target σ factors are often unknown and the sensing modules acting upstream from the PSS diverge according to the bacterial species. Indeed, they belong to either two-component systems or complex pathways as the stressosome or Chemosensory Systems (CS). Based on a phylogenetic analysis, we propose that the sensing module in Gram-negative bacteria is often a CS." @default.
- W2794234037 created "2018-03-29" @default.
- W2794234037 creator A5002929352 @default.
- W2794234037 creator A5023064900 @default.
- W2794234037 creator A5056771049 @default.
- W2794234037 creator A5068122114 @default.
- W2794234037 creator A5082058198 @default.
- W2794234037 date "2018-02-19" @default.
- W2794234037 modified "2023-09-23" @default.
- W2794234037 title "Regulation of σ factors by conserved partner switches controlled by divergent signalling systems" @default.
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