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- W2794250470 abstract "Cytochrome c oxidase is a remarkable energy transducer that seems to work almost purely by Coulombic principles without the need for significant protein conformational changes. In recent years it has become possible to follow key partial reactions of the catalytic cycle in real time, both with respect to electron and proton movements. These experiments have largely set the stage for the proton pump mechanism. The structures of the catalytic binuclear heme‑copper site that is common to the huge family of heme‑copper oxidases, are today well understood throughout the catalytic cycle of oxygen reduction to water based on both spectroscopic studies and quantum chemical calculations. Here, we briefly review this progress, and add some recent details into how the proton pump mechanism is protected from failure by leakage." @default.
- W2794250470 created "2018-03-29" @default.
- W2794250470 creator A5000095767 @default.
- W2794250470 creator A5091246390 @default.
- W2794250470 date "2018-09-01" @default.
- W2794250470 modified "2023-10-01" @default.
- W2794250470 title "Proton pumping by cytochrome c oxidase – A 40 year anniversary" @default.
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- W2794250470 doi "https://doi.org/10.1016/j.bbabio.2018.03.009" @default.
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