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- W2794260034 abstract "Human thymidylate synthase (hTS) has an important role in DNA biosynthesis, thus it is essential for cell survival. TS is involved in the folate pathways, specifically in the de novo pyrimidine biosynthesis. Structure and functions are intimately correlated, account for cellular activity and, in a broader view, with in vivo mechanisms. hTS is a target for anticancer agents, some of which are clinical drugs. The understanding of the detailed mechanism of TS inhibition by currently used drugs and of the interaction with the mechanism of action of other anticancer agents can suggest new perspective of TS inhibition able to improve the anticancer effect and to overcome drug resistance. TS-targeting drugs in therapy today are inhibitors that bind at the active site and that mostly resemble the substrates. Nonsubstrate analogs offer an opportunity for allosteric binding and novel mode of inhibition in the cancer cells. This chapter illustrates the relationship among the large number of hTS actions at molecular and clinical levels, its role as a target for ovarian cancer therapy, in particular in cases of overexpression of hTS and other folate proteins such as those induced by platinum drug treatments, and address the potential combination of TS inhibitors with other suitable anticancer agents." @default.
- W2794260034 created "2018-03-29" @default.
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- W2794260034 creator A5073099287 @default.
- W2794260034 creator A5079598961 @default.
- W2794260034 creator A5087163358 @default.
- W2794260034 date "2018-01-01" @default.
- W2794260034 modified "2023-09-26" @default.
- W2794260034 title "Human Thymidylate Synthase Inhibitors Halting Ovarian Cancer Growth" @default.
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