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- W2794264295 abstract "Establishing a non-destructive method for spatially assessing advanced glycation end-products (AGEs) is a potentially useful step toward investigating the mechanistic role of AGEs in bone quality. To test the hypothesis that the shape of the amide I in the Raman spectroscopy (RS) analysis of bone matrix changes upon AGE accumulation, we incubated paired cadaveric cortical bone in ribose or glucose solutions and in control solutions for 4 and 16 weeks, respectively, at 37°C. Acquiring 10 spectra per bone with a 20X objective and a 830 nm laser, RS was sensitive to AGE accumulation (confirmed by biochemical measurements of pentosidine and fluorescent AGEs). Hyp/Pro ratio increased upon glycation using either 0.1 M ribose, 0.5 M ribose or 0.5 M glucose. Glycation also decreased the amide I sub-peak ratios (cm-1 ) 1668/1638 and 1668/1610 when directly calculated using either second derivative spectrum or local maxima of difference spectrum, though the processing method (eg, averaged spectrum vs individual spectra) to minimize noise influenced detection of differences for the ribose-incubated bones. Glycation however did not affect these sub-peak ratios including the matrix maturity ratio (1668/1690) when calculated using indirect sub-band fitting. The amide I sub-peak ratios likely reflected changes in the collagen I structure." @default.
- W2794264295 created "2018-03-29" @default.
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- W2794264295 date "2018-05-06" @default.
- W2794264295 modified "2023-10-14" @default.
- W2794264295 title "Assessing glycation‐mediated changes in human cortical bone with Raman spectroscopy" @default.
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- W2794264295 doi "https://doi.org/10.1002/jbio.201700352" @default.
- W2794264295 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6231413" @default.
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- W2794264295 hasPublicationYear "2018" @default.
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