Matches in SemOpenAlex for { <https://semopenalex.org/work/W2794265066> ?p ?o ?g. }
- W2794265066 endingPage "18" @default.
- W2794265066 startingPage "18" @default.
- W2794265066 abstract "The Popeye domain containing (POPDC) genes encode transmembrane proteins, which are abundantly expressed in striated muscle cells. Hallmarks of the POPDC proteins are the presence of three transmembrane domains and the Popeye domain, which makes up a large part of the cytoplasmic portion of the protein and functions as a cAMP-binding domain. Interestingly, despite the prediction of structural similarity between the Popeye domain and other cAMP binding domains, at the protein sequence level they strongly differ from each other suggesting an independent evolutionary origin of POPDC proteins. Loss-of-function experiments in zebrafish and mouse established an important role of POPDC proteins for cardiac conduction and heart rate adaptation after stress. Loss-of function mutations in patients have been associated with limb-girdle muscular dystrophy and AV-block. These data suggest an important role of these proteins in the maintenance of structure and function of striated muscle cells." @default.
- W2794265066 created "2018-03-29" @default.
- W2794265066 creator A5028137643 @default.
- W2794265066 date "2018-03-13" @default.
- W2794265066 modified "2023-10-18" @default.
- W2794265066 title "The Popeye Domain Containing Genes and Their Function as cAMP Effector Proteins in Striated Muscle" @default.
- W2794265066 cites W1803102843 @default.
- W2794265066 cites W1885709862 @default.
- W2794265066 cites W1960465430 @default.
- W2794265066 cites W1964878104 @default.
- W2794265066 cites W1970607639 @default.
- W2794265066 cites W1974772536 @default.
- W2794265066 cites W1975204805 @default.
- W2794265066 cites W1978365857 @default.
- W2794265066 cites W1978828633 @default.
- W2794265066 cites W1979411530 @default.
- W2794265066 cites W1991240772 @default.
- W2794265066 cites W1992778391 @default.
- W2794265066 cites W2004781384 @default.
- W2794265066 cites W2012036787 @default.
- W2794265066 cites W2012439821 @default.
- W2794265066 cites W2014303946 @default.
- W2794265066 cites W2021988272 @default.
- W2794265066 cites W2025478498 @default.
- W2794265066 cites W2029416847 @default.
- W2794265066 cites W2044229517 @default.
- W2794265066 cites W2044825415 @default.
- W2794265066 cites W2046185560 @default.
- W2794265066 cites W2048659292 @default.
- W2794265066 cites W2049778443 @default.
- W2794265066 cites W2051514127 @default.
- W2794265066 cites W2056921690 @default.
- W2794265066 cites W2064463774 @default.
- W2794265066 cites W2071023093 @default.
- W2794265066 cites W2078037416 @default.
- W2794265066 cites W2082406934 @default.
- W2794265066 cites W2084817526 @default.
- W2794265066 cites W2085086233 @default.
- W2794265066 cites W2085532094 @default.
- W2794265066 cites W2087072817 @default.
- W2794265066 cites W2088500540 @default.
- W2794265066 cites W2097158209 @default.
- W2794265066 cites W2109788465 @default.
- W2794265066 cites W2111694965 @default.
- W2794265066 cites W2114135306 @default.
- W2794265066 cites W2116496305 @default.
- W2794265066 cites W2128803395 @default.
- W2794265066 cites W2129420873 @default.
- W2794265066 cites W2132828339 @default.
- W2794265066 cites W2149796373 @default.
- W2794265066 cites W2158337573 @default.
- W2794265066 cites W2160054565 @default.
- W2794265066 cites W2160210116 @default.
- W2794265066 cites W2167344126 @default.
- W2794265066 cites W2169638287 @default.
- W2794265066 cites W2193044843 @default.
- W2794265066 cites W2292358354 @default.
- W2794265066 cites W2337722877 @default.
- W2794265066 cites W2357365910 @default.
- W2794265066 cites W2558337182 @default.
- W2794265066 cites W2577171598 @default.
- W2794265066 cites W2622310303 @default.
- W2794265066 cites W2674118028 @default.
- W2794265066 cites W2739833500 @default.
- W2794265066 cites W2756153289 @default.
- W2794265066 cites W2756287241 @default.
- W2794265066 cites W2784097241 @default.
- W2794265066 cites W2792146447 @default.
- W2794265066 cites W2794118674 @default.
- W2794265066 cites W4210614356 @default.
- W2794265066 doi "https://doi.org/10.3390/jcdd5010018" @default.
- W2794265066 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5872366" @default.
- W2794265066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29534001" @default.
- W2794265066 hasPublicationYear "2018" @default.
- W2794265066 type Work @default.
- W2794265066 sameAs 2794265066 @default.
- W2794265066 citedByCount "23" @default.
- W2794265066 countsByYear W27942650662018 @default.
- W2794265066 countsByYear W27942650662019 @default.
- W2794265066 countsByYear W27942650662020 @default.
- W2794265066 countsByYear W27942650662021 @default.
- W2794265066 countsByYear W27942650662022 @default.
- W2794265066 countsByYear W27942650662023 @default.
- W2794265066 crossrefType "journal-article" @default.
- W2794265066 hasAuthorship W2794265066A5028137643 @default.
- W2794265066 hasBestOaLocation W27942650661 @default.
- W2794265066 hasConcept C104317684 @default.
- W2794265066 hasConcept C118892022 @default.
- W2794265066 hasConcept C14036430 @default.
- W2794265066 hasConcept C144647389 @default.
- W2794265066 hasConcept C170493617 @default.
- W2794265066 hasConcept C190062978 @default.
- W2794265066 hasConcept C24530287 @default.
- W2794265066 hasConcept C2776878037 @default.
- W2794265066 hasConcept C41625074 @default.
- W2794265066 hasConcept C51785407 @default.
- W2794265066 hasConcept C54355233 @default.
- W2794265066 hasConcept C86803240 @default.