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- W2794265299 abstract "Spinal cord injury (SCI) represents an extremely debilitating condition for which no efficacious treatment is available. One of the main contributors to the inhospitable environment found in SCI is the vascular disruption that happens in the moment of lesion, that leads to a compromise in the blood-spinal cord barrier (BSCB) and to a cascade of events that include infiltration of inflammatory cells, ischemia and intraparenchymal hemorrhage. Due to the unsatisfactory nature of revascularization following SCI, restoring vascular perfusion and the BSCB seems an interesting way of modulating the lesion environment into a regenerative phenotype, with a potential increase in functional recovery. Biomaterials have interesting features to enhance such therapies, and in fact have been applied as angiogenic promoters in other pathologies. Thus, the present mini-review intends to show the importance that biomaterials may have in the development of therapeutic approaches that restore proper vascularization and the BSCB." @default.
- W2794265299 created "2018-03-29" @default.
- W2794265299 creator A5001094739 @default.
- W2794265299 creator A5014397554 @default.
- W2794265299 creator A5053468048 @default.
- W2794265299 creator A5070575402 @default.
- W2794265299 date "2018-02-27" @default.
- W2794265299 modified "2023-10-16" @default.
- W2794265299 title "The Role of Biomaterials as Angiogenic Modulators of Spinal Cord Injury: Mimetics of the Spinal Cord, Cell and Angiogenic Factor Delivery Agents" @default.
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- W2794265299 doi "https://doi.org/10.3389/fphar.2018.00164" @default.
- W2794265299 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5835322" @default.
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- W2794265299 hasPublicationYear "2018" @default.
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