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• W2794297527 abstract "Objective: There is controversy about the diagnostic criteria, prevalence, symptoms, and spirometry characteristics of asthma–chronic obstructive pulmonary disease (COPD) overlap (ACO). Recent data indicate that the fixed method for diagnosing airway obstruction (AO) may overestimate ACO prevalence in the elderly, and a variable method may be more accurate. We aimed at estimating ACO prevalence in a general population sample and comparing patient and clinical features in subjects with ACO, COPD, and asthma. Methods: We analyzed data from a cross-sectional study estimating COPD prevalence in randomly selected adults aged 20–79 years in Verona, Italy, and estimated prevalence and analyzed characteristics of asthma, COPD, and ACO. ACO was defined as AO (Forced Expiratory Volume in one second–FEV1/ Forced Vital Capacity–FVC < Lower Limit of Normal–LLN), highly positive bronchodilator test (≥15% increase in FEV1 and FVC ≥400 mL), and personal self-reported history of physician diagnosed asthma and atopy. Results: One thousand two hundred and thirty-six patients were included; 207 (16.7%) had asthma, COPD, or ACO (mean ages: 61.2, 59.7, and 57.2 years, respectively). The 3 groups had similar clinical and demographic variables; however, spirometry revealed differences between ACO and COPD patients, particularly post-bronchodilator FEV1 reversibility, which was detected in ACO and asthma patients but not in those with COPD. Conclusion: ACO prevalence in Northern Italy was estimated at 2.1%, in the range of values reported by previous studies. Marked differences between ACO and COPD revealed by spirometry may have important clinical implications in terms of treatment for patients with ACO." @default.
• W2794297527 created "2018-03-29" @default.
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• W2794297527 date "2018-02-08" @default.
• W2794297527 modified "2023-10-14" @default.
• W2794297527 title "Prevalence and features of asthma–chronic obstructive pulmonary disease overlap in Northern Italy general population" @default.
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• W2794297527 doi "https://doi.org/10.1080/02770903.2018.1424190" @default.
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