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• W2794304315 endingPage "e13064" @default.
• W2794304315 startingPage "e13064" @default.
• W2794304315 abstract "Background Helicobacter pylori has been previously linked with preeclampsia on the basis of altered angiogenesis and activation of inflammatory cytokines. Purpose The purpose of the present systematic review is to summarise current evidence concerning the correlation of the two diseases. Materials and Methods We searched the Medline (1966-2017), Scopus (2004-2017), Clinicaltrials.gov (2008-2017) EMBASE (1980-2017), and Cochrane Central Register of Controlled Trials CENTRAL (1999-2017) databases. We selected all observational studies (both prospective and retrospective) that reported the incidence of preeclampsia among women with H. Pylori infection. Statistical meta-analysis was performed with the RevMan 5.3 software. Results Fourteen studies were finally included in this review, which included a total number of 9787 women. Nine percentage of these had preeclampsia (879 women). The evaluation of studies with the ROBINS-I tool revealed low to moderate risk of bias. H. pylori IgG seropositivity was significantly more prevalent in preeclamptic than in healthy pregnant women (9391 women, OR: 2.32, 95% CI [1.55, 3.46]). The frequency of anti-CagA antibodies was also higher in pregnancies complicated with preeclampsia (3275 women, OR: 3.97, 95% CI [1.55, 10.19]). Conclusion The findings of our study support that H. pylori infection doubles the risk of developing preeclampsia. The exact pathophysiological processes, however, remain poorly investigated and future experimental studies are needed to shed light on the underlying mechanisms." @default.
• W2794304315 created "2018-03-29" @default.
• W2794304315 creator A5040168210 @default.
• W2794304315 creator A5061553289 @default.
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• W2794304315 date "2018-02-01" @default.
• W2794304315 modified "2023-09-26" @default.
• W2794304315 title "<i>Helicobacter pylori</i> infection increases the risk of developing preeclampsia: A meta-analysis of observational studies" @default.
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• W2794304315 doi "https://doi.org/10.1111/ijcp.13064" @default.
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• W2794304315 hasPublicationYear "2018" @default.
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