FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2794310273> ?p ?o ?g. }

• W2794310273 endingPage "816" @default.
• W2794310273 startingPage "806" @default.
• W2794310273 abstract "Improvement in growth and fatness traits are the main objectives in pig all breeding programs. Tenth rib backfat thickness (10RIBBFT) and days to 100 kg (D100), which are good predictors of carcass lean content and growth rate, respectively, are economically important traits and also main breeding target traits in pigs. To investigate the genetic mechanisms of 10RIBBFT and D100 of pigs, we sampled 1,137 and 888 pigs from 2 Yorkshire populations of American and British origin, respectively, and conducted genome-wide association study (GWAS) through combined analysis and meta-analysis, to identify SNPs associated with 10RIBBFT and D100. A total of 11 and 7 significant SNPs were identified by combined analysis for 10RIBBFT and D100, respectively. And in meta-analysis, 8 and 7 significant SNPs were identified for 10RIBBFT and D100, respectively. Among them, 6 and 5 common significant SNPs in two analysis results were, respectively, identified associated with 10RIBBFT and D100, and correspondingly explained 2.09% and 0.52% of the additive genetic variance of 10RIBBFT and D100. Further bioinformatics analysis revealed 10 genes harboring or close to these common significant SNPs, 5 for 10RIBBFT and 5 for D100. In particular, Gene Ontology analysis highlighted 6 genes, PCK1, ANGPTL3, EEF1A2, TNFAIP8L3, PITX2, and PLA2G12, as promising candidate genes relevant with backfat thickness and growth. PCK1, ANGPTL3, EEF1A2, and TNFAIP8L3 could influence backfat thickness through phospholipid transport, regulation of lipid metabolic process through the glycerophospholipid biosynthesis and metabolism pathway, the metabolism of lipids and lipoproteins pathway. PITX2 has a crucial role in skeletal muscle tissue development and animal organ morphogenesis, and PLA2G12A plays a role in the lipid catabolic and phospholipid catabolic processes, which both are involved in the body weight pathway. All these candidate genes could directly or indirectly influence fat production and growth in Yorkshire pigs. Our findings provide novel insights into the genetic basis of growth and fatness traits in pigs. The candidate genes for D100 and 10RIBBFT are worthy of further investigation." @default.
• W2794310273 created "2018-03-29" @default.
• W2794310273 creator A5003601280 @default.
• W2794310273 creator A5029724408 @default.
• W2794310273 creator A5030306268 @default.
• W2794310273 creator A5037028048 @default.
• W2794310273 creator A5038361535 @default.
• W2794310273 creator A5046250326 @default.
• W2794310273 creator A5062278266 @default.
• W2794310273 creator A5065663120 @default.
• W2794310273 creator A5066703211 @default.
• W2794310273 creator A5071006086 @default.
• W2794310273 creator A5079504300 @default.
• W2794310273 creator A5088221613 @default.
• W2794310273 date "2018-03-01" @default.
• W2794310273 modified "2023-09-23" @default.
• W2794310273 title "A genome-wide association study of growth and fatness traits in two pig populations with different genetic backgrounds" @default.
• W2794310273 cites W1585356823 @default.
• W2794310273 cites W1604072917 @default.
• W2794310273 cites W1920270740 @default.
• W2794310273 cites W1969093830 @default.
• W2794310273 cites W1982114608 @default.
• W2794310273 cites W1983486297 @default.
• W2794310273 cites W1998919815 @default.
• W2794310273 cites W2000058087 @default.
• W2794310273 cites W2021457448 @default.
• W2794310273 cites W2024248225 @default.
• W2794310273 cites W2033151532 @default.
• W2794310273 cites W2067715889 @default.
• W2794310273 cites W2071876602 @default.
• W2794310273 cites W2077763475 @default.
• W2794310273 cites W2099085143 @default.
• W2794310273 cites W2103181374 @default.
• W2794310273 cites W2117371360 @default.
• W2794310273 cites W2133520037 @default.
• W2794310273 cites W2153898919 @default.
• W2794310273 cites W2154075898 @default.
• W2794310273 cites W2156072758 @default.
• W2794310273 cites W2187583278 @default.
• W2794310273 cites W2274449307 @default.
• W2794310273 cites W2318829551 @default.
• W2794310273 cites W2415518390 @default.
• W2794310273 cites W2415679889 @default.
• W2794310273 cites W2511114578 @default.
• W2794310273 cites W2565546217 @default.
• W2794310273 cites W2581307143 @default.
• W2794310273 cites W2607404091 @default.
• W2794310273 doi "https://doi.org/10.1093/jas/skx038" @default.
• W2794310273 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6093525" @default.
• W2794310273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29528397" @default.
• W2794310273 hasPublicationYear "2018" @default.
• W2794310273 type Work @default.
• W2794310273 sameAs 2794310273 @default.
• W2794310273 citedByCount "34" @default.
• W2794310273 countsByYear W27943102732019 @default.
• W2794310273 countsByYear W27943102732020 @default.
• W2794310273 countsByYear W27943102732021 @default.
• W2794310273 countsByYear W27943102732022 @default.
• W2794310273 countsByYear W27943102732023 @default.
• W2794310273 crossrefType "journal-article" @default.
• W2794310273 hasAuthorship W2794310273A5003601280 @default.
• W2794310273 hasAuthorship W2794310273A5029724408 @default.
• W2794310273 hasAuthorship W2794310273A5030306268 @default.
• W2794310273 hasAuthorship W2794310273A5037028048 @default.
• W2794310273 hasAuthorship W2794310273A5038361535 @default.
• W2794310273 hasAuthorship W2794310273A5046250326 @default.
• W2794310273 hasAuthorship W2794310273A5062278266 @default.
• W2794310273 hasAuthorship W2794310273A5065663120 @default.
• W2794310273 hasAuthorship W2794310273A5066703211 @default.
• W2794310273 hasAuthorship W2794310273A5071006086 @default.
• W2794310273 hasAuthorship W2794310273A5079504300 @default.
• W2794310273 hasAuthorship W2794310273A5088221613 @default.
• W2794310273 hasBestOaLocation W27943102732 @default.
• W2794310273 hasConcept C104317684 @default.
• W2794310273 hasConcept C106208931 @default.
• W2794310273 hasConcept C134018914 @default.
• W2794310273 hasConcept C135763542 @default.
• W2794310273 hasConcept C153209595 @default.
• W2794310273 hasConcept C186413461 @default.
• W2794310273 hasConcept C4733338 @default.
• W2794310273 hasConcept C54355233 @default.
• W2794310273 hasConcept C69991583 @default.
• W2794310273 hasConcept C86803240 @default.
• W2794310273 hasConceptScore W2794310273C104317684 @default.
• W2794310273 hasConceptScore W2794310273C106208931 @default.
• W2794310273 hasConceptScore W2794310273C134018914 @default.
• W2794310273 hasConceptScore W2794310273C135763542 @default.
• W2794310273 hasConceptScore W2794310273C153209595 @default.
• W2794310273 hasConceptScore W2794310273C186413461 @default.
• W2794310273 hasConceptScore W2794310273C4733338 @default.
• W2794310273 hasConceptScore W2794310273C54355233 @default.
• W2794310273 hasConceptScore W2794310273C69991583 @default.
• W2794310273 hasConceptScore W2794310273C86803240 @default.
• W2794310273 hasFunder F4320321001 @default.
• W2794310273 hasIssue "3" @default.
• W2794310273 hasLocation W27943102731 @default.
• W2794310273 hasLocation W27943102732 @default.
• W2794310273 hasLocation W27943102733 @default.

• next