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- W2794318307 startingPage "163" @default.
- W2794318307 abstract "Pattern separation, the ability to independently represent and store similar experiences, is a crucial facet of episodic memory. Growing evidence suggests that the hippocampus possesses unique circuitry that is computationally capable of resolving mnemonic interference by using pattern separation. In this Review, we discuss recent advances in the understanding of this process and evaluate the caveats and limitations of linking across animal and human studies. We summarize clinical and translational studies using methods that are sensitive to pattern separation impairments, an approach that stems from the fact that the hippocampus is a major site of disruption in many brain disorders. We critically evaluate the assumptions that guide fundamental and translational studies in this area. Finally, we suggest guidelines for future research and offer ways to overcome potential interpretational challenges to increase the utility of pattern separation as a construct that can further understanding of both memory processes and brain disease. The authors review the latest evidence on hippocampal pattern separation, survey recent data from cognitive tasks testing pattern separation and their application to clinical studies, and evaluate the assumptions that guide studies in the area." @default.
- W2794318307 created "2018-03-29" @default.
- W2794318307 creator A5005626969 @default.
- W2794318307 creator A5081832387 @default.
- W2794318307 date "2018-01-25" @default.
- W2794318307 modified "2023-10-11" @default.
- W2794318307 title "Integrating new findings and examining clinical applications of pattern separation" @default.
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