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- W2794331012 abstract "The decline in stroke mortality observed over the past 50 years has been attributed, in part, to improved implementation of high blood pressure (BP) treatment and control strategies based on the most current evidence from clinical research studies and randomized controlled trials (RCTs).1 The reduction in stroke risks coincides with the shift to lower systolic BP (SBP) distributions in the US adult population for all age groups.1 However, critical clinical questions remain about the treatment, control, and prevention of high BP. New evidence from RCTs and meta-analyses2–6 is expected to have an important positive impact on hypertension guidelines, clinical practice, and future research. Because stroke risk is substantially associated with BP levels and hypertension treatment and control, raised BP and stroke reduction is so heavily tied to BP control, stroke prevention is a key driving force for clinical practice decisions. As a component of the 2017 International Stroke Conference, the American Heart Association, American Stroke Association, and World Hypertension League cosponsored session focused on impact of recent hypertension studies, meta-analyses and new clinical guidelines on stroke risk reduction, and implications for future research.The Prospective Studies Collaboration7 showed a log-linear relationship between BP and stroke declining with lower BP values right down to <120 mm Hg systolic and <70 mm Hg diastolic. Further, a meta-analysis of 147 RCTs of antihypertensive therapy the percentage reduction in stroke with BP reduction down to a mean of 110/70 mm Hg regardless of their BP before treatment.8 Another systematic review in patients with diabetes mellitus reported a decrease of 13% in the risk of stroke for each 5 mm Hg reduction in SBP, and by 11.5% for each 2 mm Hg reduction in diastolic BP.9 In another meta-analysis of 123 studies, Ettehad et al4 provided support for lowering SBP to …" @default.
- W2794331012 created "2018-03-29" @default.
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- W2794331012 date "2018-03-01" @default.
- W2794331012 modified "2023-10-18" @default.
- W2794331012 title "Implications of Recent Clinical Trials and Hypertension Guidelines on Stroke and Future Cerebrovascular Research" @default.
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- W2794331012 doi "https://doi.org/10.1161/strokeaha.117.019379" @default.
- W2794331012 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5829017" @default.
- W2794331012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29467237" @default.
- W2794331012 hasPublicationYear "2018" @default.
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