Matches in SemOpenAlex for { <https://semopenalex.org/work/W2794331085> ?p ?o ?g. }
- W2794331085 abstract "Abstract Novel stimuli attract our attention, promote exploratory behavior, and facilitate learning. Atypical habituation and aberrant novelty exploration have been related with the severity of Autism Spectrum Disorders (ASD) but the underlying neuronal circuits are unknown. Here, we report that dopamine (DA) neurons of the ventral tegmental area (VTA) promote the behavioral responses to novel social stimuli, support preference for social novelty, and mediate the reinforcing properties of novel social interaction. Social novelty exploration is associated with the insertion of calcium-permeable GluA2-lacking AMPA-type glutamate receptors at excitatory synapses on VTA DA neurons. These novelty-dependent synaptic adaptations only persist upon repeated exposure to social stimuli and sustain social interaction. Global or DA neuron-specific inactivation of the ASD risk gene Neuroligin3 alters both social novelty exploration and the reinforcing properties of social stimuli. These behavioral deficits are accompanied by an aberrant expression of non-canonical GluA2-lacking AMPA-receptors at excitatory synapses on VTA DA neurons and an occlusion of novelty-induced synaptic plasticity. Altogether, these findings causally link impaired novelty exploration in an ASD mouse model to VTA DA circuit dysfunction." @default.
- W2794331085 created "2018-03-29" @default.
- W2794331085 creator A5002276509 @default.
- W2794331085 creator A5003447475 @default.
- W2794331085 creator A5014713970 @default.
- W2794331085 creator A5024821078 @default.
- W2794331085 creator A5048029784 @default.
- W2794331085 creator A5061918050 @default.
- W2794331085 creator A5066008651 @default.
- W2794331085 date "2018-03-12" @default.
- W2794331085 modified "2023-10-18" @default.
- W2794331085 title "Neuronal signature of social novelty exploration in the VTA: implication for Autism Spectrum Disorder" @default.
- W2794331085 cites W1567738273 @default.
- W2794331085 cites W1602757251 @default.
- W2794331085 cites W1617352969 @default.
- W2794331085 cites W1806596184 @default.
- W2794331085 cites W1870304014 @default.
- W2794331085 cites W1916096396 @default.
- W2794331085 cites W1928242363 @default.
- W2794331085 cites W1966403223 @default.
- W2794331085 cites W1967112350 @default.
- W2794331085 cites W1968162091 @default.
- W2794331085 cites W1969453369 @default.
- W2794331085 cites W1973138133 @default.
- W2794331085 cites W1973218389 @default.
- W2794331085 cites W1974814280 @default.
- W2794331085 cites W1977514547 @default.
- W2794331085 cites W1979595525 @default.
- W2794331085 cites W1981365366 @default.
- W2794331085 cites W1987314226 @default.
- W2794331085 cites W1989395462 @default.
- W2794331085 cites W1991686351 @default.
- W2794331085 cites W1991721037 @default.
- W2794331085 cites W1993271745 @default.
- W2794331085 cites W1996589230 @default.
- W2794331085 cites W1998033984 @default.
- W2794331085 cites W2004002023 @default.
- W2794331085 cites W2004813278 @default.
- W2794331085 cites W2010164205 @default.
- W2794331085 cites W2011382233 @default.
- W2794331085 cites W2012203722 @default.
- W2794331085 cites W2022561563 @default.
- W2794331085 cites W2032849430 @default.
- W2794331085 cites W2032988342 @default.
- W2794331085 cites W2042529649 @default.
- W2794331085 cites W2045405667 @default.
- W2794331085 cites W2045821490 @default.
- W2794331085 cites W2054086319 @default.
- W2794331085 cites W2057250808 @default.
- W2794331085 cites W2057308155 @default.
- W2794331085 cites W2057596714 @default.
- W2794331085 cites W2059763388 @default.
- W2794331085 cites W2062328738 @default.
- W2794331085 cites W2069961692 @default.
- W2794331085 cites W2082523159 @default.
- W2794331085 cites W2087480671 @default.
- W2794331085 cites W2088446168 @default.
- W2794331085 cites W2091028497 @default.
- W2794331085 cites W2091680313 @default.
- W2794331085 cites W2099168883 @default.
- W2794331085 cites W2100054850 @default.
- W2794331085 cites W2103488566 @default.
- W2794331085 cites W2109059823 @default.
- W2794331085 cites W2109091674 @default.
- W2794331085 cites W2110065237 @default.
- W2794331085 cites W2110468270 @default.
- W2794331085 cites W2110665798 @default.
- W2794331085 cites W2111030679 @default.
- W2794331085 cites W2117726420 @default.
- W2794331085 cites W2122623425 @default.
- W2794331085 cites W2122905516 @default.
- W2794331085 cites W2124087467 @default.
- W2794331085 cites W2125147395 @default.
- W2794331085 cites W2127190848 @default.
- W2794331085 cites W2140986639 @default.
- W2794331085 cites W2147609603 @default.
- W2794331085 cites W2150333287 @default.
- W2794331085 cites W2151299944 @default.
- W2794331085 cites W2162250902 @default.
- W2794331085 cites W2162507318 @default.
- W2794331085 cites W2165144227 @default.
- W2794331085 cites W2169220559 @default.
- W2794331085 cites W2171592792 @default.
- W2794331085 cites W2229474614 @default.
- W2794331085 cites W2269038554 @default.
- W2794331085 cites W2409899008 @default.
- W2794331085 cites W2438121633 @default.
- W2794331085 cites W2508644210 @default.
- W2794331085 cites W2509099448 @default.
- W2794331085 cites W2530703593 @default.
- W2794331085 cites W2573028465 @default.
- W2794331085 cites W2573876973 @default.
- W2794331085 cites W2583012620 @default.
- W2794331085 cites W2591909999 @default.
- W2794331085 cites W2734580914 @default.
- W2794331085 cites W2743963693 @default.
- W2794331085 cites W2760672146 @default.
- W2794331085 cites W2772417881 @default.
- W2794331085 doi "https://doi.org/10.1101/280537" @default.
- W2794331085 hasPublicationYear "2018" @default.