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- W2794341976 endingPage "574" @default.
- W2794341976 startingPage "565" @default.
- W2794341976 abstract "Transcription factor IKZF1 (IKAROS) acts as a critical regulator of lymphoid differentiation and is frequently deleted or mutated in B-cell precursor acute lymphoblastic leukemia. IKZF1 gene defects are associated with inferior treatment outcome in both childhood and adult B-cell precursor acute lymphoblastic leukemia and occur in more than 70% of BCR-ABL1-positive and BCR-ABL1-like cases of acute lymphoblastic leukemia. Over the past few years, much has been learned about the tumor suppressive function of IKZF1 during leukemia development and the molecular pathways that relate to its impact on treatment outcome. In this review, we provide a concise overview on the role of IKZF1 during normal lymphopoiesis and the pathways that contribute to leukemia pathogenesis as a consequence of altered IKZF1 function. Furthermore, we discuss different mechanisms by which IKZF1 alterations impose therapy resistance on leukemic cells, including enhanced cell adhesion and modulation of glucocorticoid response." @default.
- W2794341976 created "2018-03-29" @default.
- W2794341976 creator A5020171094 @default.
- W2794341976 creator A5026391738 @default.
- W2794341976 creator A5038325579 @default.
- W2794341976 date "2018-03-08" @default.
- W2794341976 modified "2023-10-14" @default.
- W2794341976 title "The many faces of IKZF1 in B-cell precursor acute lymphoblastic leukemia" @default.
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