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• W2794344128 abstract "// Anders Woetmann 1, * , Morten Alhede 2, * , Sally Dabelsteen 3, * , Thomas Bjarnsholt 4, 2 , Morten Rybtke 4, 2 , Claudia Nastasi 1 , Thorbjørn Krejsgaard 1 , Mads Hald Andersen 5 , Charlotte M. Bonefeld 1 , Carsten Geisler 1 , Michael Givskov 4, 5, 6 and Niels Odum 1 1 Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark 2 Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark 3 Department of Odontology, University of Copenhagen, Copenhagen, Denmark 4 Costerton Biofilm Center, University of Copenhagen, Copenhagen, Denmark 5 Center for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital, Herlev, Denmark 6 Singapore Centre for Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, Singapore * These authors contributed equally to this work Correspondence to: Niels Odum, email: ndum@sund.ku.dk Keywords: IL-26; antimicrobial peptide; staphylococcus aureus enterotoxins; chronic wounds; superantigens staphylococcus pseudomonas; Immunology Received: October 15, 2017      Accepted: February 24, 2018      Published: April 13, 2018 ABSTRACT Anti-microbial peptides are produced at outer and inner surfaces by epithelia and innate immune cells in response to bacterial infection. Staphylococcus aureus is an enterotoxin producing, Gram-positive pathogen, which is a major cause of soft tissue infections and life-threatening bacteremia and sepsis. Here we show that (i) skin T cells in chronic wounds infected with S. aureus express interleukin-26 (IL-26) in situ , (ii) staphylococcal enterotoxins (SE) trigger IL-26 expression in T cell lines and primary skin T cells, and (iii) IL-26 triggers death and inhibits biofilm formation and growth of S. aureus . Thus, we provide novel evidence that IL-26 is an anti-microbial peptide produced by T cells in response to SE. Accordingly, we propose that IL-26 producing T cells take part in the innate immune response to SE producing S. aureus and thus play a novel role in the primary innate immune defense in addition to their classical role in adaptive immunity." @default.
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• W2794344128 date "2018-04-13" @default.
• W2794344128 modified "2023-10-03" @default.
• W2794344128 title "Interleukin-26 (IL-26) is a novel anti-microbial peptide produced by T cells in response to staphylococcal enterotoxin" @default.
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• W2794344128 doi "https://doi.org/10.18632/oncotarget.24603" @default.
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