FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2794345691> ?p ?o ?g. }

• W2794345691 endingPage "245" @default.
• W2794345691 startingPage "228" @default.
• W2794345691 abstract "The purpose of this study is to investigate structural and ultrastructural alterations in the rat's brain cerebral cortex after aspartame (ASP) treatment and to evaluate the possible ameliorating role of N-acetyl-L-cysteine (NAC) and folic acid (FA). Forty adult rats were divided into four equal groups: Group I, received appropriate vehicle only and served as control. Group II, received oral doses of both NAC (600 mg/kg body weight (b.w.)) and FA (12 mg/kg b.w.) daily for 42 days. Group III, received oral doses of ASP (500 mg/kg b.w.) daily for 42 days. Group IV, received both NAC and FA, concurrently with ASP at the same doses, route and period of administration of the previous groups. Histological examination of the cerebral cortex of ASP-treated rats showed severe degenerative changes, especially in the nerve cells. Some of these cells appeared shrunken, irregular in shape, while the others appeared swollen and were surrounded by pericellular halos. Immunohistochemical and morphometric study of ASP-treated group revealed a weak B-cell lymphoma-2 (Bcl-2) immunoexpression in the cytoplasm of many cells, while intense positive immunoreaction for glial fibrillary acidic protein (GFAP) was observed in the cytoplasm and processes of astrocytes compared to control group with statistically significant difference (p < 0.001). Light microscopic results were confirmed by ultrastructural findings. However, NAC and FA in combination had an obvious protective effect against ASP-induced injury in the rat's cerebral cortex. In conclusion, these results suggested that NAC combined with FA can ameliorate the toxic effect of ASP on the rat's cerebral cortex." @default.
• W2794345691 created "2018-03-29" @default.
• W2794345691 creator A5005231628 @default.
• W2794345691 creator A5039099313 @default.
• W2794345691 creator A5091744997 @default.
• W2794345691 date "2018-02-26" @default.
• W2794345691 modified "2023-09-26" @default.
• W2794345691 title "The possible protective effect of<i>N</i>-acetyl-L-cysteine and folic acid in combination against aspartame-induced cerebral cortex neurotoxicity in adult male rats: a light and transmission electron microscopic study" @default.
• W2794345691 cites W1529233910 @default.
• W2794345691 cites W1531373906 @default.
• W2794345691 cites W1586196635 @default.
• W2794345691 cites W1608663004 @default.
• W2794345691 cites W1632828799 @default.
• W2794345691 cites W1756111479 @default.
• W2794345691 cites W177810299 @default.
• W2794345691 cites W1861690947 @default.
• W2794345691 cites W1919851123 @default.
• W2794345691 cites W1921596438 @default.
• W2794345691 cites W1941525064 @default.
• W2794345691 cites W1945836171 @default.
• W2794345691 cites W1971963364 @default.
• W2794345691 cites W1974302922 @default.
• W2794345691 cites W1974951849 @default.
• W2794345691 cites W1975111111 @default.
• W2794345691 cites W1984308054 @default.
• W2794345691 cites W1986211748 @default.
• W2794345691 cites W2002178803 @default.
• W2794345691 cites W2004661554 @default.
• W2794345691 cites W2006216450 @default.
• W2794345691 cites W2011371104 @default.
• W2794345691 cites W2011614389 @default.
• W2794345691 cites W2013209652 @default.
• W2794345691 cites W2015560738 @default.
• W2794345691 cites W2018531655 @default.
• W2794345691 cites W2021420626 @default.
• W2794345691 cites W2027586059 @default.
• W2794345691 cites W2029549234 @default.
• W2794345691 cites W2045288779 @default.
• W2794345691 cites W204582743 @default.
• W2794345691 cites W2046461866 @default.
• W2794345691 cites W2052211882 @default.
• W2794345691 cites W2066768357 @default.
• W2794345691 cites W2066791472 @default.
• W2794345691 cites W2072967133 @default.
• W2794345691 cites W2095399683 @default.
• W2794345691 cites W2095975236 @default.
• W2794345691 cites W2100625035 @default.
• W2794345691 cites W2105388269 @default.
• W2794345691 cites W2114872570 @default.
• W2794345691 cites W2122382179 @default.
• W2794345691 cites W2123739790 @default.
• W2794345691 cites W2127091487 @default.
• W2794345691 cites W2137290347 @default.
• W2794345691 cites W2138980273 @default.
• W2794345691 cites W2141135691 @default.
• W2794345691 cites W2141344764 @default.
• W2794345691 cites W2153010844 @default.
• W2794345691 cites W2157547287 @default.
• W2794345691 cites W2202286106 @default.
• W2794345691 cites W2266209009 @default.
• W2794345691 cites W2319748250 @default.
• W2794345691 cites W2413444695 @default.
• W2794345691 cites W2510456830 @default.
• W2794345691 cites W2564063689 @default.
• W2794345691 cites W281801904 @default.
• W2794345691 doi "https://doi.org/10.1080/01913123.2018.1440270" @default.
• W2794345691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29482444" @default.
• W2794345691 hasPublicationYear "2018" @default.
• W2794345691 type Work @default.
• W2794345691 sameAs 2794345691 @default.
• W2794345691 citedByCount "3" @default.
• W2794345691 countsByYear W27943456912020 @default.
• W2794345691 countsByYear W27943456912023 @default.
• W2794345691 crossrefType "journal-article" @default.
• W2794345691 hasAuthorship W2794345691A5005231628 @default.
• W2794345691 hasAuthorship W2794345691A5039099313 @default.
• W2794345691 hasAuthorship W2794345691A5091744997 @default.
• W2794345691 hasConcept C126322002 @default.
• W2794345691 hasConcept C134018914 @default.
• W2794345691 hasConcept C142724271 @default.
• W2794345691 hasConcept C169760540 @default.
• W2794345691 hasConcept C185592680 @default.
• W2794345691 hasConcept C204232928 @default.
• W2794345691 hasConcept C2777348757 @default.
• W2794345691 hasConcept C2779147919 @default.
• W2794345691 hasConcept C2779491297 @default.
• W2794345691 hasConcept C2779652256 @default.
• W2794345691 hasConcept C2780495277 @default.
• W2794345691 hasConcept C2781041448 @default.
• W2794345691 hasConcept C29730261 @default.
• W2794345691 hasConcept C2992333117 @default.
• W2794345691 hasConcept C55493867 @default.
• W2794345691 hasConcept C71924100 @default.
• W2794345691 hasConcept C86803240 @default.
• W2794345691 hasConcept C87555872 @default.
• W2794345691 hasConcept C98274493 @default.
• W2794345691 hasConceptScore W2794345691C126322002 @default.
• W2794345691 hasConceptScore W2794345691C134018914 @default.

• next