FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2794348564> ?p ?o ?g. }

• W2794348564 endingPage "220" @default.
• W2794348564 startingPage "214" @default.
• W2794348564 abstract "In patients suffering from major depressive disorder, non-response to initial antidepressant monotherapy is relatively common. The use of treatment algorithms may optimize and enhance treatment outcome.A single-center 3-phase treatment algorithm was evaluated for inpatients with major depressive disorder, i.e. phase I (n = 85): 7 weeks optimal antidepressant monotherapy (imipramine or venlafaxine); phase II (n = 39): 4 weeks subsequent plasma level-targeted dose lithium addition in case of insufficient improvement of antidepressant monotherapy; and phase III (n = 8): subsequent electroconvulsive therapy in case of insufficient improvement of antidepressant‑lithium treatment. Overall feasibility of the 3-phase algorithm was determined by the number of dropouts, and overall efficacy was evaluated using weekly scores on the 17-item Hamilton Rating Scale for Depression (HAM-D) during the treatment phases of the algorithm. This paper is based on an RCT comparing the two antidepressants in phase I and adding lithium in phase II.Of the 85 patients analyzed, overall dropout during the 3-phase treatment algorithm was 24 (28%) patients. When analyzing the 3-phase treatment algorithm on a modified intention-to-treat basis, 39 (46%) patients achieved complete remission (HAM-D score ≤ 7) by the end of the algorithm. Regarding response (HAM-D score reduction ≥50%): of the 85 patients, 60 (71%) were responders by the end of the algorithm.The favorable outcome of the 3-phase treatment algorithm emphasizes the importance of pursuing stepwise antidepressant treatment in patients who are nonresponsive to the first antidepressant.This study protocol is registered at http://www.controlled-trials.com, Pharmacological Treatment of Depression (identifier: ISRCTN73221288)." @default.
• W2794348564 created "2018-03-29" @default.
• W2794348564 creator A5005530081 @default.
• W2794348564 creator A5011765104 @default.
• W2794348564 creator A5018211312 @default.
• W2794348564 creator A5046352428 @default.
• W2794348564 creator A5090997121 @default.
• W2794348564 date "2018-06-01" @default.
• W2794348564 modified "2023-10-18" @default.
• W2794348564 title "Outcome of a three-phase treatment algorithm for inpatients with melancholic depression" @default.
• W2794348564 cites W1604967837 @default.
• W2794348564 cites W1969229684 @default.
• W2794348564 cites W1975895811 @default.
• W2794348564 cites W1981356642 @default.
• W2794348564 cites W1985285470 @default.
• W2794348564 cites W1991912111 @default.
• W2794348564 cites W2010317561 @default.
• W2794348564 cites W2011392433 @default.
• W2794348564 cites W2012918642 @default.
• W2794348564 cites W2023634568 @default.
• W2794348564 cites W2039061513 @default.
• W2794348564 cites W2045485789 @default.
• W2794348564 cites W2050323651 @default.
• W2794348564 cites W2060568618 @default.
• W2794348564 cites W2060889081 @default.
• W2794348564 cites W2062644160 @default.
• W2794348564 cites W2098349325 @default.
• W2794348564 cites W2098667423 @default.
• W2794348564 cites W2099215360 @default.
• W2794348564 cites W2101963851 @default.
• W2794348564 cites W2114613490 @default.
• W2794348564 cites W2119698096 @default.
• W2794348564 cites W2122656874 @default.
• W2794348564 cites W2171166616 @default.
• W2794348564 cites W2417939032 @default.
• W2794348564 doi "https://doi.org/10.1016/j.pnpbp.2018.03.002" @default.
• W2794348564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29505804" @default.
• W2794348564 hasPublicationYear "2018" @default.
• W2794348564 type Work @default.
• W2794348564 sameAs 2794348564 @default.
• W2794348564 citedByCount "4" @default.
• W2794348564 countsByYear W27943485642021 @default.
• W2794348564 countsByYear W27943485642022 @default.
• W2794348564 countsByYear W27943485642023 @default.
• W2794348564 crossrefType "journal-article" @default.
• W2794348564 hasAuthorship W2794348564A5005530081 @default.
• W2794348564 hasAuthorship W2794348564A5011765104 @default.
• W2794348564 hasAuthorship W2794348564A5018211312 @default.
• W2794348564 hasAuthorship W2794348564A5046352428 @default.
• W2794348564 hasAuthorship W2794348564A5090997121 @default.
• W2794348564 hasConcept C11413529 @default.
• W2794348564 hasConcept C118552586 @default.
• W2794348564 hasConcept C126322002 @default.
• W2794348564 hasConcept C138496976 @default.
• W2794348564 hasConcept C139719470 @default.
• W2794348564 hasConcept C142724271 @default.
• W2794348564 hasConcept C15744967 @default.
• W2794348564 hasConcept C162324750 @default.
• W2794348564 hasConcept C204787440 @default.
• W2794348564 hasConcept C2776466505 @default.
• W2794348564 hasConcept C2776466888 @default.
• W2794348564 hasConcept C2776867660 @default.
• W2794348564 hasConcept C2777198177 @default.
• W2794348564 hasConcept C2778541603 @default.
• W2794348564 hasConcept C2779144063 @default.
• W2794348564 hasConcept C2779145073 @default.
• W2794348564 hasConcept C2779177272 @default.
• W2794348564 hasConcept C2780051608 @default.
• W2794348564 hasConcept C2781161787 @default.
• W2794348564 hasConcept C2993089816 @default.
• W2794348564 hasConcept C3018023364 @default.
• W2794348564 hasConcept C41008148 @default.
• W2794348564 hasConcept C71924100 @default.
• W2794348564 hasConcept C83849319 @default.
• W2794348564 hasConceptScore W2794348564C11413529 @default.
• W2794348564 hasConceptScore W2794348564C118552586 @default.
• W2794348564 hasConceptScore W2794348564C126322002 @default.
• W2794348564 hasConceptScore W2794348564C138496976 @default.
• W2794348564 hasConceptScore W2794348564C139719470 @default.
• W2794348564 hasConceptScore W2794348564C142724271 @default.
• W2794348564 hasConceptScore W2794348564C15744967 @default.
• W2794348564 hasConceptScore W2794348564C162324750 @default.
• W2794348564 hasConceptScore W2794348564C204787440 @default.
• W2794348564 hasConceptScore W2794348564C2776466505 @default.
• W2794348564 hasConceptScore W2794348564C2776466888 @default.
• W2794348564 hasConceptScore W2794348564C2776867660 @default.
• W2794348564 hasConceptScore W2794348564C2777198177 @default.
• W2794348564 hasConceptScore W2794348564C2778541603 @default.
• W2794348564 hasConceptScore W2794348564C2779144063 @default.
• W2794348564 hasConceptScore W2794348564C2779145073 @default.
• W2794348564 hasConceptScore W2794348564C2779177272 @default.
• W2794348564 hasConceptScore W2794348564C2780051608 @default.
• W2794348564 hasConceptScore W2794348564C2781161787 @default.
• W2794348564 hasConceptScore W2794348564C2993089816 @default.
• W2794348564 hasConceptScore W2794348564C3018023364 @default.
• W2794348564 hasConceptScore W2794348564C41008148 @default.
• W2794348564 hasConceptScore W2794348564C71924100 @default.
• W2794348564 hasConceptScore W2794348564C83849319 @default.

• next