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- W2794359561 endingPage "184" @default.
- W2794359561 startingPage "173" @default.
- W2794359561 abstract "Antimicrobial peptides (AMPs) are typically thought of as molecular hole punchers that directly kill pathogens by membrane permeation. However, recent work has shown that AMPs are pleiotropic, multifunctional molecules that can strongly modulate immune responses. In this review, we provide a historical overview of the immunomodulatory properties of natural and synthetic antimicrobial peptides, with a special focus on human cathelicidin and defensins. We also summarize the various mechanisms of AMP immune modulation and outline key structural rules underlying the recently-discovered phenomenon of AMP-mediated Toll-like receptor (TLR) signaling. In particular, we describe several complementary studies demonstrating how AMPs self-assemble with nucleic acids to form nanocrystalline complexes that amplify TLR-mediated inflammation. In a broader scope, we discuss how this new conceptual framework allows for the prediction of immunomodulatory behavior in AMPs, how the discovery of hidden antimicrobial activity in known immune signaling proteins can inform these predictions, and how these findings reshape our understanding of AMPs in normal host defense and autoimmune disease." @default.
- W2794359561 created "2018-03-29" @default.
- W2794359561 creator A5005220470 @default.
- W2794359561 creator A5066307655 @default.
- W2794359561 creator A5078191755 @default.
- W2794359561 date "2019-04-01" @default.
- W2794359561 modified "2023-10-12" @default.
- W2794359561 title "Modulation of toll-like receptor signaling by antimicrobial peptides" @default.
- W2794359561 cites W1185390759 @default.
- W2794359561 cites W1491097392 @default.
- W2794359561 cites W1495270894 @default.
- W2794359561 cites W1512310505 @default.
- W2794359561 cites W1514540900 @default.
- W2794359561 cites W1515106383 @default.
- W2794359561 cites W1522866020 @default.
- W2794359561 cites W1525462211 @default.
- W2794359561 cites W1527143867 @default.
- W2794359561 cites W1542775986 @default.
- W2794359561 cites W1546703330 @default.
- W2794359561 cites W1590649050 @default.
- W2794359561 cites W1596376754 @default.
- W2794359561 cites W1598171376 @default.
- W2794359561 cites W1598910326 @default.
- W2794359561 cites W1667782349 @default.
- W2794359561 cites W1673257055 @default.
- W2794359561 cites W1675847437 @default.
- W2794359561 cites W1751680809 @default.
- W2794359561 cites W1754273948 @default.
- W2794359561 cites W1790693342 @default.
- W2794359561 cites W1834013341 @default.
- W2794359561 cites W1842002390 @default.
- W2794359561 cites W1880127774 @default.
- W2794359561 cites W1921818371 @default.
- W2794359561 cites W1923164049 @default.
- W2794359561 cites W1930598094 @default.
- W2794359561 cites W1943160106 @default.
- W2794359561 cites W1950305586 @default.
- W2794359561 cites W1951507118 @default.
- W2794359561 cites W1967810254 @default.
- W2794359561 cites W1968669292 @default.
- W2794359561 cites W1968763142 @default.
- W2794359561 cites W1969072247 @default.
- W2794359561 cites W1970291282 @default.
- W2794359561 cites W1971290197 @default.
- W2794359561 cites W1973737910 @default.
- W2794359561 cites W1978962348 @default.
- W2794359561 cites W1982027655 @default.
- W2794359561 cites W1983601981 @default.
- W2794359561 cites W1989584792 @default.
- W2794359561 cites W1991621444 @default.
- W2794359561 cites W1992049128 @default.
- W2794359561 cites W1994052523 @default.
- W2794359561 cites W1994370838 @default.
- W2794359561 cites W1994391392 @default.
- W2794359561 cites W1994726986 @default.
- W2794359561 cites W1995029980 @default.
- W2794359561 cites W1995047265 @default.
- W2794359561 cites W1995586746 @default.
- W2794359561 cites W1996671942 @default.
- W2794359561 cites W2001422402 @default.
- W2794359561 cites W2001747259 @default.
- W2794359561 cites W2002152440 @default.
- W2794359561 cites W2003086561 @default.
- W2794359561 cites W2003164428 @default.
- W2794359561 cites W2004336750 @default.
- W2794359561 cites W2007770980 @default.
- W2794359561 cites W2008939854 @default.
- W2794359561 cites W2008968208 @default.
- W2794359561 cites W2010655741 @default.
- W2794359561 cites W2011842440 @default.
- W2794359561 cites W2012393861 @default.
- W2794359561 cites W2018421387 @default.
- W2794359561 cites W2022273444 @default.
- W2794359561 cites W2022680502 @default.
- W2794359561 cites W2025050505 @default.
- W2794359561 cites W2025374951 @default.
- W2794359561 cites W2025412364 @default.
- W2794359561 cites W2026884617 @default.
- W2794359561 cites W2030118018 @default.
- W2794359561 cites W2033106764 @default.
- W2794359561 cites W2033777503 @default.
- W2794359561 cites W2038267036 @default.
- W2794359561 cites W2044729290 @default.
- W2794359561 cites W2044757050 @default.
- W2794359561 cites W2045101135 @default.
- W2794359561 cites W2045384882 @default.
- W2794359561 cites W2052655247 @default.
- W2794359561 cites W2052844959 @default.
- W2794359561 cites W2053772103 @default.
- W2794359561 cites W2054602599 @default.
- W2794359561 cites W2054805318 @default.
- W2794359561 cites W2055527896 @default.
- W2794359561 cites W2055856930 @default.
- W2794359561 cites W2058613673 @default.
- W2794359561 cites W2059775282 @default.
- W2794359561 cites W2060351820 @default.
- W2794359561 cites W2062350041 @default.
- W2794359561 cites W2063088766 @default.