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- W2794366931 abstract "Introduction: Treating liver tumors by in situ ablation techniques such as laser induced thermotherapy (LITT) creates thermal lesions with complex lesion geometry. The aim of this study was to develop and evaluate a computer-simulated 3-D irradiation model for predicting the thermal volume in LITT. Material and Methods: Light and heat distribu tion in the tissue was calculated by using a Monte Carlo simulation. We first established a tissue database (human/animal!healthy/tumorous, n=120 samples). A 3-D image of the coagulation volume was created and the simulation results were correlated to those in vivo in 15 domestic pigs. The animals were randomized into three groups: normal hepatic perfusion; interrupted perfusion by Pringle maneuver; i.a. embolization by starch micro spheres. Results: Simulating the coagulation volume required 28.5 (23 - 27) min. Simulated or in vivo interrupted perfusion led to a 4.5-fold (DSM) or lO-fold (Pringle) increase in le sion volume. The deviation in the diameter between the simulation and in vivo data was a maximum of 3-1% ± 0.3 (LITTmono), 2.6% ± 0.3 (LITTpringle) and 15.6% ± (LITTDsM). Con clusion: The developed 3-D irradiation model showed very good prediction of the coagu lation volume in LITT. It is now possible for the first time to make a statement about the expected lesion geometry and the application parameters required for reliable tumor de struction during in situ ablation procedures." @default.
- W2794366931 created "2018-03-29" @default.
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- W2794366931 date "2001-01-01" @default.
- W2794366931 modified "2023-09-27" @default.
- W2794366931 title "In-vivo Evaluation eines computergestiitzten 3-D-Simulations modells zur interstitiellen Tumorablation an der Schweineleber unter normaler und unterbrochener hepatischer Perfusion In vivo evaluation of a 3-~ computer-simulated model for interstitial tumor ablation in porcine liver with normal and interrupted hepatic perfusion" @default.
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