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- W2794368007 abstract "Oocytes uniquely accumulate cytoplasmic constituents to support early embryogenesis. This unique specialization is accompanied by acquisition of a large size and by execution of asymmetric meiotic divisions that preserve precious ooplasm through the expulsion of minimal size polar bodies. While often taken for granted, these basic features of oogenesis necessitate unique specializations of the meiotic apparatus. These include a chromatin‐sourced RanGTP gradient that restricts spindle size by defining a spatial domain where meiotic spindles form, acentriolar centrosomes that rely on microtubule organizing centers to form spindle poles, and an actin‐based mechanism for asymmetric spindle positioning. Additionally, localized protein synthesis to support spindle formation is achieved in the spindle forming region, whilst protein synthesis is reduced elsewhere in the ooplasm. This is achieved through enrichment of spindle‐related mRNAs in the spindle forming region combined with local PLK1‐mediated phosphorylation and inactivation of the translational repressor EIF4EBP1. This allows PLK1 to function as an important regulatory nexus through which endogenous and exogenous signals can impact spindle formation and function, and highlights the important role that PLK1 may have in maintaining oocyte quality and fertility." @default.
- W2794368007 created "2018-03-29" @default.
- W2794368007 creator A5036576262 @default.
- W2794368007 creator A5084285342 @default.
- W2794368007 date "2018-03-01" @default.
- W2794368007 modified "2023-09-30" @default.
- W2794368007 title "Meeting the meiotic challenge: Specializations in mammalian oocyte spindle formation" @default.
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- W2794368007 doi "https://doi.org/10.1002/mrd.22967" @default.
- W2794368007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5864121" @default.
- W2794368007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29411912" @default.
- W2794368007 hasPublicationYear "2018" @default.
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