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- W2794379113 abstract "The addition of nitrogen dioxide (NO2) to the double bond of unsaturated fatty acids yields an array of electrophilic nitro-fatty acids (NO2-FA) with unique biochemical and signaling properties. During the last decade, NO2-FA have been shown to exert a protective role in various inflammatory and metabolic disorders. NO2-FA exert their biological effects primarily by regulating two central physiological adaptive responses: the canonical inflammatory signaling and metabolic pathways. In this mini-review, we summarize current knowledge on the regulatory role of NO2-FA in the inflammatory and metabolic response via regulation of nuclear factor kappa B (NF-κB) and peroxisome proliferator-activated receptor γ (PPARγ), master regulators of inflammation and metabolism. Moreover, the engagement of novel signaling and metabolic pathways influenced by NO2-FA, beyond NF-κB and PPAR signaling, is discussed herein." @default.
- W2794379113 created "2018-03-29" @default.
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- W2794379113 date "2018-08-01" @default.
- W2794379113 modified "2023-10-14" @default.
- W2794379113 title "Inflammatory signaling and metabolic regulation by nitro-fatty acids" @default.
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- W2794379113 doi "https://doi.org/10.1016/j.niox.2018.03.017" @default.
- W2794379113 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6151155" @default.
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