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• W2794394009 abstract "Heavy menstrual bleeding (HMB), which affects as many as 30% of women, has a well- established negative impact on quality of life and work productivity [ 1 Lukes A.S. Baker J. Eder S. Adomako T.L. Daily menstrual blood loss and quality of life in women with heavy menstrual bleeding. Womens Health. 2012; 8: 503-511 Crossref PubMed Scopus (24) Google Scholar , 2 Singh S. Best C. Dunn S. Leyland N. Wolfman W.L. Abnormal uterine bleeding in premenopausal woman. SOGC Clinical Practice Guideline 292. J Obstet Gynecol Can. 2013; 35: S1-S28 PubMed Scopus (38) Google Scholar ]. In women with chronic HMB in the absence of known anatomic abnormalities (fibroids, adenomyosis), options such as non-steroidal anti-inflammatory drugs (NSAIDs) [ [3] Lethaby A. Duckitt K. Farquhar C. Nonsteroidal anti-inflammatory drugs for heavy menstrual bleeding. Cochrane Database Syst Rev. 2013; 000400 Google Scholar ], combined hormonal contraceptives [ [4] Jensen J.T. Parke S. Mellinger U. Machlitt A. Fraser I.S. Effective treatment of heavy menstrual bleeding with estradiol valerate and dienogest: a randomized controlled trial. Obstet Gynecol. 2011; 117: 777-787 Crossref PubMed Scopus (101) Google Scholar ], the levonorgestrel intrauterine system [ [5] Mansour D. Modern management of abnormal uterine bleeding—the levonorgestrel intra-uterine system. Best Pract Res Clin Obstet Gynaecol. 2007; 21: 1107-1121 Crossref Scopus (36) Google Scholar ], danazol [ [6] Chimbira T.H. Anderson A.B.M. Naish C. Cope E. Turnbull A.C. Reduction of menstrual blood loss by danazol in unexplained menorrhagia: lack of effect of placebo. Br J Obstet Gynaecol. 1980; 87: 1152-1158 Crossref PubMed Scopus (68) Google Scholar ] and tranexamic acid [ [7] Lukes A.S. Moore K.A. Muse K.N. Gersten J.K. Hecht B.R. Edlund M. et al. Tranexamic acid treatment for heavy menstrua lbleeding: a randomized controlled trial. Obstet Gynecol. 2010; 116: 865-875 Crossref PubMed Scopus (181) Google Scholar ] show varying degrees of efficacy for reduction of menstrual flow and are often able to restore normal day-to-day function." @default.
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• W2794394009 date "2018-07-01" @default.
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• W2794394009 title "Heavy menstrual bleeding: is tranexamic acid a safe adjunct to combined hormonal contraception?" @default.
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• W2794394009 doi "https://doi.org/10.1016/j.contraception.2018.02.008" @default.
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