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• W2794403049 abstract "Type 2 diabetes has been recognized as the most prominent of all diabetes types, contributing to global morbidity and mortality. Availability and cost of treatment with little or no side effect especially in developing countries remains a huge burden. This has led to the search of affordable alternative therapies especially from natural products from medicinal plants. In this study, the antidiabetic effect of the methanolic extract, dichloromethane (DCM), butanol (BuOH) and aqueous fractions of Clerodendrum volubile leaves were investigated in type 2 diabetic rats for their effect on glucose homeostasis, serum insulin level and hepatic biomarkers, lipid profile, pancreatic redox balance and Ca2+ levels, and β-cell distribution and function. The DCM was further fractionated to isolate the active compounds, biochanin and 5,7,4'-Trimethoxykaempferol. They were investigated for their toxicity and ADMET properties, α–glucosidase and angiotensin I converting enzyme (ACE) inhibitory activities in silico. There were significant (p<0.05) decrease in blood glucose, cholesterol, LDL-C, vLDL-C, triglyceride, AST and ALT levels in all treated groups, with DCM showing the best activity. All treated rats showed significantly (p<0.05) improved anti-oxidative activities. Treatment with the DCM fraction led to significant (p<0.05) increased serum insulin and pancreatic Ca2+ levels as well as improved β-cell distribution and function. DCM also showed improved glucose tolerance. DCM fraction dose – dependently inhibited ACE activity. The toxicity class of the isolated compounds was predicted to be 5. They were also predicted to be potent inhibitors of cytochrome P (CYPs) 1A2, 2D6 and 3A4. They docked well with α-glucosidase and ACE. These results indicate the therapeutic effect of the leaves against type 2 diabetes, with the DCM fraction being the most potent which may be attributed to the isolated flavones. It further suggests antihypertensive potentials of the DCM fraction. However, inhibition of CYPs by the flavones may suggest caution in usage with other prescribed drugs metabolized by these enzymes." @default.
• W2794403049 created "2018-03-29" @default.
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• W2794403049 date "2018-02-01" @default.
• W2794403049 modified "2023-09-30" @default.
• W2794403049 title "Suppressive Effects of Clerodendrum volubile P Beauv. [Labiatae] Methanolic Extract and Its Fractions on Type 2 Diabetes and Its Complications" @default.
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• W2794403049 cites W1570541053 @default.
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• W2794403049 cites W1599342152 @default.
• W2794403049 cites W1612982626 @default.
• W2794403049 cites W1775749144 @default.
• W2794403049 cites W1967727920 @default.
• W2794403049 cites W1976745215 @default.
• W2794403049 cites W1976766573 @default.
• W2794403049 cites W1989844152 @default.
• W2794403049 cites W1992203795 @default.
• W2794403049 cites W1998666012 @default.
• W2794403049 cites W2006370393 @default.
• W2794403049 cites W2008694342 @default.
• W2794403049 cites W2009615797 @default.
• W2794403049 cites W2010943728 @default.
• W2794403049 cites W2014004380 @default.
• W2794403049 cites W2017602185 @default.
• W2794403049 cites W2025122196 @default.
• W2794403049 cites W2025205258 @default.
• W2794403049 cites W2035085337 @default.
• W2794403049 cites W2038977244 @default.
• W2794403049 cites W2044414390 @default.
• W2794403049 cites W2047734203 @default.
• W2794403049 cites W2056066400 @default.
• W2794403049 cites W2064261045 @default.
• W2794403049 cites W2067670322 @default.
• W2794403049 cites W2074031373 @default.
• W2794403049 cites W2075228225 @default.
• W2794403049 cites W2078281227 @default.
• W2794403049 cites W2089125273 @default.
• W2794403049 cites W2090111195 @default.
• W2794403049 cites W2093905050 @default.
• W2794403049 cites W2106280473 @default.
• W2794403049 cites W2108050119 @default.
• W2794403049 cites W2112954588 @default.
• W2794403049 cites W2115709630 @default.
• W2794403049 cites W2116404316 @default.
• W2794403049 cites W2123284306 @default.
• W2794403049 cites W2123795043 @default.
• W2794403049 cites W2126547325 @default.
• W2794403049 cites W2131909681 @default.
• W2794403049 cites W2132806782 @default.
• W2794403049 cites W2134724243 @default.
• W2794403049 cites W2137676811 @default.
• W2794403049 cites W2142436967 @default.
• W2794403049 cites W2147479689 @default.
• W2794403049 cites W2158468809 @default.
• W2794403049 cites W2162992895 @default.
• W2794403049 cites W2176901216 @default.
• W2794403049 cites W2185465651 @default.
• W2794403049 cites W2202210344 @default.
• W2794403049 cites W2331211363 @default.
• W2794403049 cites W2342325276 @default.
• W2794403049 cites W2509200051 @default.
• W2794403049 cites W2528189507 @default.
• W2794403049 cites W2555428532 @default.
• W2794403049 cites W2564935857 @default.
• W2794403049 cites W2569189597 @default.
• W2794403049 cites W2585136170 @default.
• W2794403049 cites W2589891535 @default.
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• W2794403049 cites W2732591598 @default.
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• W2794403049 doi "https://doi.org/10.3389/fphar.2018.00008" @default.
• W2794403049 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5799276" @default.
• W2794403049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29449808" @default.
• W2794403049 hasPublicationYear "2018" @default.
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