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• W2794403280 abstract "// Norazalina Saad 1, 2 , Ramiro Alberio 3 , Andrew D. Johnson 4 , Richard D. Emes 1, 5 , Tom C. Giles 1, 5 , Philip Clarke 6 , Anna M. Grabowska 6 and Cinzia Allegrucci 1 1 School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, UK 2 Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia 3 School of Biosciences, Sutton Bonington Campus, Loughborough, LE12 5RD, UK 4 School of Life Sciences, University of Nottingham, QMC, Nottingham, NG7 2UH, UK 5 Advanced Data Analysis Centre (ADAC), University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, UK 6 Cancer Biology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, QMC, Nottingham, NG7 2UH, UK Correspondence to: Cinzia Allegrucci, email: cinzia.allegrucci@nottingham.ac.uk Keywords: reprogramming; tumour reversion; dormancy; breast cancer; axolotl oocytes Received: September 30, 2017     Accepted: February 27, 2018     Published: March 23, 2018 ABSTRACT Inducing stable control of tumour growth by tumour reversion is an alternative approach to cancer treatment when eradication of the disease cannot be achieved. The process requires re-establishment of normal control mechanisms that are lost in cancer cells so that abnormal proliferation can be halted. Embryonic environments can reset cellular programmes and we previously showed that axolotl oocyte extracts can reprogram breast cancer cells and reverse their tumorigenicity. In this study, we analysed the gene expression profiles of oocyte extract-treated tumour xenografts to show that tumour reprogramming involves cell cycle arrest and acquisition of a quiescent state. Tumour dormancy is associated with increased P27 expression, restoration of RB function and downregulation of mitogen-activated signalling pathways. We also show that the quiescent state is associated with increased levels of H4K20me3 and decreased H4K20me1, an epigenetic profile leading to chromatin compaction. The epigenetic reprogramming induced by oocyte extracts is required for RB hypophosphorylation and induction of P27 expression, both occurring during exposure to the extracts and stably maintained in reprogrammed tumour xenografts. Therefore, this study demonstrates the value of oocyte molecules for inducing tumour reversion and for the development of new chemoquiescence-based therapies." @default.
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• W2794403280 date "2018-03-23" @default.
• W2794403280 modified "2023-10-13" @default.
• W2794403280 title "Cancer reversion with oocyte extracts is mediated by cell cycle arrest and induction of tumour dormancy" @default.
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• W2794403280 doi "https://doi.org/10.18632/oncotarget.24664" @default.
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