FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2794420565> ?p ?o ?g. }

• W2794420565 endingPage "6544" @default.
• W2794420565 startingPage "6535" @default.
• W2794420565 abstract "Abstract RE (Radiation enteritis) has been characterized by the inflammation reaction, and in this study, we aim to explore inflammatory cytokines and underlying mechanism involved in the pathogenesis of RE. Luciferase assay was performed to explore whether polymorphism affected the expression of let‐7, and also validated let‐7 directly regulated f IL‐6 expression. Then Elisa was performed to study the mechanism of rs13293512 polymorphism associated with enteritis occurrence. And Western‐blot and real‐time PCR were performed to verify the relationship between let‐7 and IL‐6. 380 colorectal cancer patients were recruited, and all participants were genotyped. We found that occurrence probability of enteritis patients carried CC genotype (32%) was much higher than that in TT and TC groups (15%). In addition, we showed that the presence of the minor (C) allele of the polymorphism in the promoter region of let‐7 substantially reduced the transcription activity of let‐7, furthermore, we validated that let‐7 directly regulated IL‐6 expression by using luciferase reporter system. Moreover, IL‐6 was highly expressed in peripheral blood and colonic mucosa samples genotyped as CC compared to those in TT and TC groups, furthermore, IL‐6 was highly expressed in peripheral blood and colonic mucosa samples from participants with enteritis than without enteritis, whereas let‐7 was highly expressed in peripheral blood and colonic mucosa samples genotyped as TT and TC compared to those in CC groups. Let‐7 polymorphism (rs13293512) was associated with risk of RE in the colorectal cancer patients who received radiotherapy." @default.
• W2794420565 created "2018-03-29" @default.
• W2794420565 creator A5019147529 @default.
• W2794420565 creator A5067896093 @default.
• W2794420565 creator A5077607330 @default.
• W2794420565 creator A5085028455 @default.
• W2794420565 creator A5091721283 @default.
• W2794420565 date "2018-04-19" @default.
• W2794420565 modified "2023-09-25" @default.
• W2794420565 title "Rs13293512 polymorphism located in the promoter region of let‐7 is associated with increased risk of radiation enteritis in colorectal cancer" @default.
• W2794420565 cites W114315274 @default.
• W2794420565 cites W1661157351 @default.
• W2794420565 cites W1965147416 @default.
• W2794420565 cites W1978271284 @default.
• W2794420565 cites W1981467511 @default.
• W2794420565 cites W1981989535 @default.
• W2794420565 cites W1987612024 @default.
• W2794420565 cites W1996590048 @default.
• W2794420565 cites W2004434518 @default.
• W2794420565 cites W2007292828 @default.
• W2794420565 cites W2026330707 @default.
• W2794420565 cites W2030166934 @default.
• W2794420565 cites W2032374311 @default.
• W2794420565 cites W2033801757 @default.
• W2794420565 cites W2041269789 @default.
• W2794420565 cites W2054139887 @default.
• W2794420565 cites W2059382687 @default.
• W2794420565 cites W2067547254 @default.
• W2794420565 cites W2079557731 @default.
• W2794420565 cites W2088243050 @default.
• W2794420565 cites W2118458597 @default.
• W2794420565 cites W2119013116 @default.
• W2794420565 cites W2124472585 @default.
• W2794420565 cites W2132195064 @default.
• W2794420565 cites W2144038313 @default.
• W2794420565 cites W2145702684 @default.
• W2794420565 cites W2146642335 @default.
• W2794420565 cites W2152310279 @default.
• W2794420565 cites W2172157901 @default.
• W2794420565 cites W2334189061 @default.
• W2794420565 cites W2474594928 @default.
• W2794420565 cites W293537719 @default.
• W2794420565 cites W4211030541 @default.
• W2794420565 doi "https://doi.org/10.1002/jcb.26733" @default.
• W2794420565 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29388713" @default.
• W2794420565 hasPublicationYear "2018" @default.
• W2794420565 type Work @default.
• W2794420565 sameAs 2794420565 @default.
• W2794420565 citedByCount "6" @default.
• W2794420565 countsByYear W27944205652021 @default.
• W2794420565 countsByYear W27944205652022 @default.
• W2794420565 countsByYear W27944205652023 @default.
• W2794420565 crossrefType "journal-article" @default.
• W2794420565 hasAuthorship W2794420565A5019147529 @default.
• W2794420565 hasAuthorship W2794420565A5067896093 @default.
• W2794420565 hasAuthorship W2794420565A5077607330 @default.
• W2794420565 hasAuthorship W2794420565A5085028455 @default.
• W2794420565 hasAuthorship W2794420565A5091721283 @default.
• W2794420565 hasConcept C101762097 @default.
• W2794420565 hasConcept C104317684 @default.
• W2794420565 hasConcept C121608353 @default.
• W2794420565 hasConcept C126322002 @default.
• W2794420565 hasConcept C135763542 @default.
• W2794420565 hasConcept C142724271 @default.
• W2794420565 hasConcept C150194340 @default.
• W2794420565 hasConcept C153911025 @default.
• W2794420565 hasConcept C180754005 @default.
• W2794420565 hasConcept C2780031333 @default.
• W2794420565 hasConcept C2780942790 @default.
• W2794420565 hasConcept C2911083071 @default.
• W2794420565 hasConcept C3019368612 @default.
• W2794420565 hasConcept C526805850 @default.
• W2794420565 hasConcept C54355233 @default.
• W2794420565 hasConcept C71924100 @default.
• W2794420565 hasConcept C86803240 @default.
• W2794420565 hasConcept C90924648 @default.
• W2794420565 hasConceptScore W2794420565C101762097 @default.
• W2794420565 hasConceptScore W2794420565C104317684 @default.
• W2794420565 hasConceptScore W2794420565C121608353 @default.
• W2794420565 hasConceptScore W2794420565C126322002 @default.
• W2794420565 hasConceptScore W2794420565C135763542 @default.
• W2794420565 hasConceptScore W2794420565C142724271 @default.
• W2794420565 hasConceptScore W2794420565C150194340 @default.
• W2794420565 hasConceptScore W2794420565C153911025 @default.
• W2794420565 hasConceptScore W2794420565C180754005 @default.
• W2794420565 hasConceptScore W2794420565C2780031333 @default.
• W2794420565 hasConceptScore W2794420565C2780942790 @default.
• W2794420565 hasConceptScore W2794420565C2911083071 @default.
• W2794420565 hasConceptScore W2794420565C3019368612 @default.
• W2794420565 hasConceptScore W2794420565C526805850 @default.
• W2794420565 hasConceptScore W2794420565C54355233 @default.
• W2794420565 hasConceptScore W2794420565C71924100 @default.
• W2794420565 hasConceptScore W2794420565C86803240 @default.
• W2794420565 hasConceptScore W2794420565C90924648 @default.
• W2794420565 hasIssue "8" @default.
• W2794420565 hasLocation W27944205651 @default.
• W2794420565 hasLocation W27944205652 @default.
• W2794420565 hasOpenAccess W2794420565 @default.

• next