FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2794425877> ?p ?o ?g. }

• W2794425877 endingPage "122" @default.
• W2794425877 startingPage "113" @default.
• W2794425877 abstract "Substantial progress has been made in the therapeutic reduction of vertebral fracture risk in patients with osteoporosis, but non-vertebral fracture risk has been improved only marginally. Human genetic studies demonstrate that the WNT16 locus is a major determinant of cortical bone thickness and non-vertebral fracture risk and mouse models with life-long Wnt16 inactivation revealed that WNT16 is a key regulator of cortical thickness. These studies, however, could not exclude that the effect of Wnt16 inactivation on cortical thickness might be caused by early developmental and/or growth effects. To determine the effect of WNT16 specifically on adult cortical bone homeostasis, Wnt16 was conditionally ablated in young adult and old mice through tamoxifen-inducible Cre-mediated recombination using CAG-Cre-ER; Wnt16 flox/flox ( Cre-Wnt16 flox/flox ) mice. First, 10-week-old Cre-Wnt16 flox/flox and Wnt16 flox/flox littermate control mice were treated with tamoxifen. Four weeks later, Wnt16 mRNA levels in cortical bone were reduced and cortical thickness in femur was decreased in Cre-Wnt16 flox/flox mice compared to Wnt16 flox/flox mice. Then, inactivation of Wnt16 in 47-week-old mice (evaluated four weeks later) resulted in a reduction of Wnt16 mRNA levels, cortical thickness and cortical bone strength with no effect on trabecular bone volume fraction. Mechanistic studies demonstrated that the reduced cortical bone thickness was caused by a combination of increased bone resorption and reduced periosteal bone formation. In conclusion, WNT16 is a crucial regulator of cortical bone thickness in young adult and old mice. We propose that new treatment strategies targeting the adult regulation of WNT16 might be useful to reduce fracture risk at cortical bone sites." @default.
• W2794425877 created "2018-03-29" @default.
• W2794425877 creator A5001946747 @default.
• W2794425877 creator A5002122520 @default.
• W2794425877 creator A5004164970 @default.
• W2794425877 creator A5014074360 @default.
• W2794425877 creator A5019689323 @default.
• W2794425877 creator A5036566833 @default.
• W2794425877 creator A5037187485 @default.
• W2794425877 creator A5041256730 @default.
• W2794425877 creator A5048857760 @default.
• W2794425877 creator A5064220321 @default.
• W2794425877 creator A5064385806 @default.
• W2794425877 creator A5069732047 @default.
• W2794425877 creator A5088412943 @default.
• W2794425877 creator A5091032474 @default.
• W2794425877 date "2018-05-01" @default.
• W2794425877 modified "2023-09-27" @default.
• W2794425877 title "Inducible Wnt16 inactivation: WNT16 regulates cortical bone thickness in adult mice" @default.
• W2794425877 cites W131928997 @default.
• W2794425877 cites W1549329940 @default.
• W2794425877 cites W1967598128 @default.
• W2794425877 cites W1981020155 @default.
• W2794425877 cites W1986085728 @default.
• W2794425877 cites W1994403900 @default.
• W2794425877 cites W2005442458 @default.
• W2794425877 cites W2019196925 @default.
• W2794425877 cites W2021693450 @default.
• W2794425877 cites W2029063697 @default.
• W2794425877 cites W2037750372 @default.
• W2794425877 cites W2037978897 @default.
• W2794425877 cites W2042742511 @default.
• W2794425877 cites W2060235532 @default.
• W2794425877 cites W2065766094 @default.
• W2794425877 cites W2066749771 @default.
• W2794425877 cites W2069259673 @default.
• W2794425877 cites W2087407206 @default.
• W2794425877 cites W2089094116 @default.
• W2794425877 cites W2096425957 @default.
• W2794425877 cites W2104357139 @default.
• W2794425877 cites W2119934014 @default.
• W2794425877 cites W2135129121 @default.
• W2794425877 cites W2136672074 @default.
• W2794425877 cites W2137696823 @default.
• W2794425877 cites W2155377428 @default.
• W2794425877 cites W2158933761 @default.
• W2794425877 cites W2160005424 @default.
• W2794425877 cites W2161984225 @default.
• W2794425877 cites W2178287479 @default.
• W2794425877 cites W2554646502 @default.
• W2794425877 cites W2613499307 @default.
• W2794425877 cites W2750085463 @default.
• W2794425877 doi "https://doi.org/10.1530/joe-18-0020" @default.
• W2794425877 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5886037" @default.
• W2794425877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29530924" @default.
• W2794425877 hasPublicationYear "2018" @default.
• W2794425877 type Work @default.
• W2794425877 sameAs 2794425877 @default.
• W2794425877 citedByCount "33" @default.
• W2794425877 countsByYear W27944258772018 @default.
• W2794425877 countsByYear W27944258772019 @default.
• W2794425877 countsByYear W27944258772020 @default.
• W2794425877 countsByYear W27944258772021 @default.
• W2794425877 countsByYear W27944258772022 @default.
• W2794425877 countsByYear W27944258772023 @default.
• W2794425877 crossrefType "journal-article" @default.
• W2794425877 hasAuthorship W2794425877A5001946747 @default.
• W2794425877 hasAuthorship W2794425877A5002122520 @default.
• W2794425877 hasAuthorship W2794425877A5004164970 @default.
• W2794425877 hasAuthorship W2794425877A5014074360 @default.
• W2794425877 hasAuthorship W2794425877A5019689323 @default.
• W2794425877 hasAuthorship W2794425877A5036566833 @default.
• W2794425877 hasAuthorship W2794425877A5037187485 @default.
• W2794425877 hasAuthorship W2794425877A5041256730 @default.
• W2794425877 hasAuthorship W2794425877A5048857760 @default.
• W2794425877 hasAuthorship W2794425877A5064220321 @default.
• W2794425877 hasAuthorship W2794425877A5064385806 @default.
• W2794425877 hasAuthorship W2794425877A5069732047 @default.
• W2794425877 hasAuthorship W2794425877A5088412943 @default.
• W2794425877 hasAuthorship W2794425877A5091032474 @default.
• W2794425877 hasBestOaLocation W27944258771 @default.
• W2794425877 hasConcept C104317684 @default.
• W2794425877 hasConcept C105702510 @default.
• W2794425877 hasConcept C126322002 @default.
• W2794425877 hasConcept C134018914 @default.
• W2794425877 hasConcept C185592680 @default.
• W2794425877 hasConcept C2781451080 @default.
• W2794425877 hasConcept C55493867 @default.
• W2794425877 hasConcept C6929976 @default.
• W2794425877 hasConcept C71924100 @default.
• W2794425877 hasConceptScore W2794425877C104317684 @default.
• W2794425877 hasConceptScore W2794425877C105702510 @default.
• W2794425877 hasConceptScore W2794425877C126322002 @default.
• W2794425877 hasConceptScore W2794425877C134018914 @default.
• W2794425877 hasConceptScore W2794425877C185592680 @default.
• W2794425877 hasConceptScore W2794425877C2781451080 @default.
• W2794425877 hasConceptScore W2794425877C55493867 @default.
• W2794425877 hasConceptScore W2794425877C6929976 @default.

• next